Factors determining the physical performance of patientswith heart failure and anemia

Authors: Kupryashov A.A., Rivnyak M.I., Koloskova N.N., Glushko L.A., Mironenko V.A., Bockeria L.A.

Company: Bakoulev National Medical Research Center for Cardiovascular Surgery, Ministry of Health of the Russian Federation, Rublevskoe shosse, 135, Moscow, 121552, Russian Federation

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Type:  Original articles

DOI: https://doi.org/10.24022/1997-3187-2019-13-4-349-362

For citation: Kupryashov A.A., Rivnyak M.I., Koloskova N.N., Glushko L.A., Mironenko V.A., Bockeria L.A. Factors determining the physical performance of patients with heart failure and anemia. Creative Cardiology. 2019; 13 (4): 349–62 (in Russ.). DOI: 10.24022/1997-3187-2019-13-4-349-362

Received / Accepted:  03.12.2019/11.12.2019

Keywords: heart failure ferropenia anemia exercise capacity

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Objective. To study is the prognoses of tolerance to exercise capacity depending on impaired hemodynamics and severity of anemia.

Material and methods. The prospective observational cohort study included 79 patients with chronic heart failure. The dependent variables were the functional physical performance class, assessed in a 6-minute walk test and based on the determination of peak oxygen consumption using a cardiorespiratory test. Indicators of morphofunctional state of the left ventricle, hematological parameters and characteristics of iron metabolism (iron, transferrin, ferritin) were considered as independent variables.

Results. When assessing physical performance on the basis of a 6-minute walk test, it was shown that higher peak oxygen consumption (с=0,767), higher concentrations of iron (с=0,524) and transferrin (с=0,368) provided a higher load tolerance, while the anaerobic threshold (с=–0,066) and hematocrit (с=–0,024) affected it negatively. When assessing physical performance on the basis of the cardiorespiratory test, it was revealed that higher oxygen consumption at rest (с=0,288) and anaerobic threshold (с=0,608), as well as hematocrit (с=0,266), suggest a greater tolerance to physical activity, while VE/VO2 (с=–0,326), VE/VCO2 (с=–0,199), end-diastolic volume (EDV) of left ventricular (LV) (с=–0,218), serum iron (с=–0,061) had negative prognostic value. It was shown that, depending on EDV LV, hematocrit, serum iron and transferrin concentrations, patients with heart failure can be combined into three clusters: with minimal laboratory and hemodynamic disorders, mainly with hemodynamic disorders and mainly with iron deficiency.

Conclusion. The level of transferrin less than 200 mg/dl in patients with heart failure associated with anemia should suggest the elimination of disorders of iron metabolism, and LV EDV more than 300 ml indicates a predominant contribution of hemodilution to a decrease in hemoglobin concentration.


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About Authors

  • Aleksey A. Kupryashov, Dr. Med. Sc., Head of Department; ORCID
  • Marina I. Rivnyak, Cardiologist
  • Nadezhda N. Koloskova, Cand. Med. Sc., Head of Department
  • Lyudmila A. Glushko, Cand. Med. Sc., Head of Group; ORCID
  • Vladimir A. Mironenko, Dr. Med. Sc., Head of Department; ORCID
  • Leo A. Bockeria, Dr. Med. Sc., Professor, Academician of RAS and RAMS, President; ORCID

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, Director of Bakoulev National Medical Research Center for Cardiovascular Surgery