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Early prevention of cardio- toxicity in cancer patients: focus on medical therapy

Authors: Akildzhonov F.R., Buziashvili Yu.I., Asymbekova E.U., Tugeeva E.F., Alimov V.P.

Company: Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russian Federation

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Type:  Reviews


DOI: https://doi.org/10.24022/1997-3187-2021-15-3-322-331

For citation: Akildzhonov F.R., Buziashvili Yu.I., Asymbekova E.U., Tugeeva E.F., Alimov V.P. Early prevention of cardiotoxicity in cancer patients: focus on medical therapy. Creative Cardiology. 2021; 15 (3): 322–31 (in Russ.). DOI: 10.24022/1997-3187-2021-15-3-322-331

Received / Accepted:  26.04.2021 / 24.08.2021

Keywords: cardiotoxicity anthracycline dexrazoxane

Full text:  

 

Abstract

Over the past few decades, cancer treatment has made significant progress in improving the quality of life and survival of cancer patients. Cancer mortality has dropped significantly thanks to the development of early screening programs, improved diagnostic algorithms, and more effective treatment options, including targeted anti-cancer drugs. At the moment, more and more attention are paid to cardiotoxicity, which develops against the background of antitumor treatment. Internationally published guidelines for this category of patients do not fully cover all problems, and there is no standardized classification system for determining cardiotoxicity. Future research is expected to identify the precise molecular and genetic mechanisms involved in cardiotoxicity, allowing the development of new targets for targeted anticancer therapy. This review presents the current data on the early prevention of chemotherapy-induced cardiotoxicity.

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About Authors

  • Firdavsdzhon R. Akildzhonov, Resident Physician; ORCID
  • Yuriy I. Buziashvili, Dr. Med. Sci., Professor, Academician of RAS, Head of Department; ORCID
  • El’mira U. Asymbekova, Dr. Med. Sci., Leading Researcher; ORCID
  • El’vina F. Tugeeva, Dr. Med. Sci., Senior Researcher; ORCID
  • Victor P. Alimov, Cardiologist; ORCID

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


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