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Interaction of low-frequency oscillations in heartrate variability and blood flow variability in distalarterial bed during treatment with metoprololin patients with prior myocardial infarction

Authors: A.R. Kiselev 1,2, 2, V.S. Khorev 3, V.A. Shvarts 1, A.S. Karavaev 3, S.A. Mironov 4, O.M. Posnenkova 2, O.L. Bockeria 1, V.I. Gridnev 2, 3

Company: 1 Bakoulev National Medical Research Center for Cardiovascular Surgery of Ministry of Health of the Russian Federation, Rublevskoe shosse, 135, Moscow, 121552, Russian Federation;
2 Saratov State Medical University n.a. V.I. Razumovsky of Ministry of Health of the Russian Federation, Bolshaya Kazachya ulitsa, 112, Saratov, 410012, Russian Federation;
3 Saratov State University n.a. N.G. Chernyshevsky, Astrakhanskaya ulitsa, 83, Saratov, 410012, Russian Federation;
4 Central Military Clinical Hospital of the Federal Security Service of the Russian Federation, Shchukinskaya ulitsa, 20, Moscow, 123182, Russian Federation.

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DOI: https://doi.org/10.24022/1997-3187-2017-11-4-315-325

For citation: Kiselev A.R., Khorev V.S., Shvartz V.A., Karavaev A.S., Mironov S.A., Posnenkova O.M., Gridnev V.I., Bockeria O.L. Interaction of low-frequency oscillations in heart rate variability and blood flow variability in distal arterial bed during treatment with metoprolol in patients with prior myocardial infarction. Kreativnaya Kardiologiya (Creative Cardiology). 2017; 11 (4): 315–25 (in Russ.). DOI:10.24022/1997-3187-2017-11-4-315-325

Received / Accepted:  18.04.2017/15.05.2017

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Abstract

Objective. We studied biophysical features of bi-directional interaction between low-frequency (LF) oscillations in heart rate variability (HRV) and distal blood flow variability, evaluated by photoplethysmogram (PPG), against the background of changes in the daily dose of metoprolol in patients with coronary heart disease and prior myocardial infarction (MI).

Material and methods. Synchronous 10-minute RR intervals (from electrocardiogram) and PPGs (from distal phalanx of left hand finger) were performed during a passive orthostatic test in 40 patients (21 men and 19 women; 63±7 years) who had MI about six months ago. The first (initial) registration was performed on 6 month after MI under treatment with metoprolol tartrate at a dose 50 and less mg/day. The second registration was performed after three months of metoprolol treatment at the maximum tolerated dosages (100 or more mg/day).

Results. Initially, there was no difference between delay times of coupling of LF-oscillations from HRV to PPG and back. Increase of metoprolol dose contributed to decrease delay time of coupling from PPG to HRV in the supine position (p=0.049). While in standing position, significant dynamics were not observed on comparison with baseline level. The changes of metoprolol dose did not affect on influence of LF-oscillations of HRV to PPG.

Conclusion. An increase of daily dose of metoprolol tartrate in patients with prior MI was associated with significant decrease of delay in effect of LF-oscillations in PPG to HRV only in supine position. In half of patients, this delay even in lower then in healthy subjects. Increase of metoprolol dose did not significantly influence to delay of feedback from HRV to PPG.

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About Authors

  • Kiselev Anton Robertovich, Dr Med. Sc., Researcher of Bakoulev National Medical Research Center for Cardiovascular Surgery, Leading Researcher of Saratov State Medical University n.a. V.I. Razumovsky, orcid.org/0000-0003-3967-3950;
  • Khorev Vladimir Sergeevich, Cand. Phys. Math. Sc., Associate Professor, orcid.org/0000-0001-6613-8940;
  • Shvarts Vladimir Aleksandrovich, Cand. Med. Sc., Junior Researcher, orcid.org/0000-0002-8931-0376;
  • Karavaev Anatoliy Sergeevich, Cand. Phys. Math. Sc., Associate Professor, Senior Researcher, orcid.org/0000-0003-4678-3648;
  • Mironov Sergey Alekseevich, Cand. Med. Sc., Cardiologist, orcid.org/0000-0001-8571-3285;
  • Posnenkova Ol’ga Mikhailovna, Dr Med. Sc., Senior Researcher, orcid.org/0000-0001-5311-005X;
  • Bockeria Ol’ga Leonidovna, Corresponding Member of Russian Academy of Sciences, Professor, Chief Researcher, Deputy Head of Department, orcid.org/0000-0002-7711-8520;
  • Gridnev Vladimir Ivanovich, Dr Med. Sc., Professor, Head of Department, orcid.org/0000-0001-6807-7934

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


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