Atrium fibrillation and enlargement of left heart chambers:pathological mechanisms of cognitive dysfunctionin cardiologic patients
Authors:
Company: A.N. Bakoulev Scientific Center for Cardiovascular Surgery; Rublevskoe shosse, 135, Moscow, 121552, Russian Federation
DOI:
Keywords: atrial fibrillation antagonists vitamin K novel oral anticoagulants stroke prevention
Abstract
The problem of cognitive dysfunction in patients with cardiovascular disorders is intensively studied at present. Deficit of cognitive functions leads to the reduced patient compliance and, as a consequence, to the decreased efficiency of the treatment. Patients with atrial fibrillation and patients with enlarged left heart chambers regularly demonstrate proneness to hypercoagulation, hypoperfusion and microemboli at cerebral circulation, which lead to development of multiple ischemic lesions and neurotrophic alterations, which underlie the cognitive dysfunction. Multiple studies showed that atrial fibrillation is an independent risk factor of cognitive dysfunction in patients after strokе and patients with normal neurological status. The association between enlarged heart chambers and cognitive dysfunction is less investigated, however, several studies in this field showed this association to be significant.References
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