Молекулярные механизмы фибрилляции предсердий: в поиске «идеального» маркера

Авторы: А.З. Жолбаева, А.Е. Табина, Е.З. Голухова

Организация:
ФГБНУ «Научный центр сердечно-сосудистой хирургии им. А.Н. Бакулева» (директор – академик РАН и РАМН Л.А. Бокерия); Рублевское шоссе, 135, Москва, 121552, Российская Федерация

Для корреспонденции: Сведения доступны для зарегистрированных пользователей.

Тип статьи: Фундаментальные вопросы кардиологии

DOI: https://doi.org/10.15275/kreatkard.2015.02.04

Ключевые слова: фибрилляция предсердий, ренин-ангиотензин-альдостероновая система, воспаление, фиброз, эндотелиальная дисфункция

Полнотекстовая версия:  

 

Аннотация

На сегодняшний день фибрилляция предсердий стала одной из важнейших проблем общественного здравоохранения и одной из основных причин увеличения расходов на систему здравоохранения. Фибрилляция предсердий ассоциируется с такими социально-экономическими проблемами, как стойкая утрата трудоспособности, когнитивные нарушения, частые госпитализации. Одним из грозных осложнений данного вида аритмии является ишемический инсульт, приводящий к инвалидизации и смерти пациента. При фибрилляции предсердий риск развития инсульта и тромбоэмболических осложнений возрастает в пять раз, сердечной недостаточности – в три раза, а риск деменции и смерти увеличивается вдвое. Мероприятия по профилактике пароксизмов фибрилляции предсердий, включающие антиаритмическую терапию и катетерную аблацию, недостаточно эффективны. Объясняется это неполным пониманием патогенетических механизмов, лежащих в основе возникновения аритмии. В данной статье продемонстрировано прогностическое значение нейрогуморальных маркеров, маркеров воспаления, фиброза, повреждения миокарда и эндотелиальной дисфункции в развитии фибрилляции предсердий и ее осложнений.

Литература

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Об авторах

Жолбаева Айгерим Замирбековна, аспирант; Табина Анастасия Евгеньевна, аспирант; Голухова Елена Зеликовна, доктор мед. наук, профессор, чл.-корр. РАН, заведующий отделением

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Лео Антонович Бокерия, доктор медицинских наук, профессор, академик РАН и РАМН, директор


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