Эндогенный фибринолиз и ишемическая болезнь сердца

Авторы: П.П. Саввинова, А.И. Калинская

Организация:
Кафедра кардиологии ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России, ул. Делегатская, 20/1, Москва, 127473, Российская Федерация

Для корреспонденции: Сведения доступны для зарегистрированных пользователей.

Раздел: Обзорные статьи

DOI: https://doi.org/10.24022/1997-3187-2018-12-4-341-352

УДК: 616.12-005.4:615.273.55

Библиографическая ссылка: Креативная кардиология. 2018; 12 (4): 341-352

Цитировать как: П.П. Саввинова, А.И. Калинская. Эндогенный фибринолиз и ишемическая болезнь сердца. Креативная кардиология. 2018; 12 (4): 341-352. DOI: 10.24022/1997-3187-2018-12-4-341-352

Поступила / Принята к печати:  27.09.2018/09.10.2018

Ключевые слова: эндогенный фибринолиз, острый инфаркт миокарда, спонтанная реперфузия

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Аннотация

Ишемическая болезнь сердца (ИБС) является одной из ведущих причин госпитализаций и смертности во всем мире. Смертность от ИБС обусловлена преимущественно острыми формами – острым коронарным синдромом, а именно острым инфарктом миокарда (ОИМ), а также его осложнениями, которые развиваются как в остром, так и в отдаленном периодах. Наиболее частый патогенетический вариант развития ОИМ – образование тромба в просвете коронарной артерии вследствие разрыва или эрозии нестабильной атеросклеротической бляшки. Сформируется ли полная или частичная окклюзия коронарной артерии, зависит от активации не только свертывающей системы, но и противо- свертывающей и фибринолитической систем. В 15,7% случаев полной окклюзии инфаркт-связанной артерии возникает спонтанное восстановление кровотока. Механизм спонтанной реперфузии до конца не ясен, важную роль в ней играет функциональное состояние эндотелия, а также активация фибринолитической системы, направленной на растворение тромба. В настоящем обзоре мы рассмотрим полученные нами и другими исследователями данные о механизме и роли активации фибринолитической системы у пациентов с ИБС, а также обсудим методы изучения фибринолиза.

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Об авторах

  • Саввинова Полина Павловна, аспирант, orcid.org/0000-0001-8596-5212;
  • Калинская Анна Ильинична, доцент, канд. мед. наук, orcid.org/0000-0003-2316-4238

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