Endogenous fibrinolysis and coronary artery disease HTML


Company: Department of Cardiology of Moscow State University of Medicine and Dentistry named after A.I. Evdokimov of Ministry of Health of the Russian Federation, Delegatskaya ulitsa, 20/1, Moscow, 127473, Russian Federation

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Heading: Reviews

UDC: 616.12-005.4:615.273.55
DOI: https://doi.org/10.24022/1997-3187-2018-12-4-341-352

For citation: Savvinova P.P., Kalinskaya A.I. Endogenous fibrinolysis and coronary artery disease. Creative Cardiology. 2018; 12 (4): 341–52 (in Russ.). DOI: 10.24022/1997-3187-2018-12-4-341-352

Received / Accepted:  27.09.2018/09.10.2018

Key Words: эндогенный фибринолиз острый инфаркт миокарда спонтанная реперфузия


Coronary artery disease remains one of the main reason for hospitalization and death all over the world. The main pathogenic variant of acute myocardial infarction is destabilization of atherosclerotic plaque with subsequent intravascular thrombosis. Whether complete or partial occlusion of the coronary artery is formed depends not only on the activation of the coagulation system, but also on the anticoagulation and fibrinolytic systems. As it was shown previously in 15.7% of cases of total occlusion of infarct-related artery the restoration of blood flow occurs spontaneously. The exact mechanism of spontaneous reperfusion is still poorly investigated. The endothelial function and the activation of the fibrinolytic system play an extremely important role in this process. In this review we present our own and literature data on the mechanism and role of fibrinolytic system activation in patients with coronary artery disease.


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About Authors

  • Polina P. Savvinova, Postgraduate, orcid.org/0000-0001-8596-5212;
  • Anna I. Kalinskaya, Associate Professor, Cand. Med. Sc., orcid.org/0000-0003-2316-4238

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, Director of Bakoulev National Medical Research Center for Cardiovascular Surgery