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The importance of inflammatory response mediators in the mechanisms of atherogenesis and their effect on the results of myocardial revascularization in patients with coronary artery disease

Authors: Iraskhanov A.Sh., Buziashvili Yu.I., Koksheneva I.V., Tugeeva E.F., Timerbulatova T.R.

Company: Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russian Federation

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Type:  Reviews


DOI: https://doi.org/10.24022/1997-3187-2023-17-3-330-340

For citation: Iraskhanov A.Sh., Buziashvili Yu.I., Koksheneva I.V., Tugeeva E.F., Timerbulatova T.R. The importance of inflammatory response mediators in the mechanisms of atherogenesis and their effect on the results of myocardial revascularization in patients with coronary artery disease. Creative Cardiology. 2023; 17 (3): 330–40 (in Russ.). DOI: 10.24022/1997-3187-2023-17-3-330-340

Received / Accepted:  25.08.2023 / 28.09.2023

Keywords: сoronary artery bypass grafting coronary artery disease coronary bypass dysfunction thrombosis atherosclerosis systemic inflammation response syndrome systemic inflammation

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Abstract

Aorto-coronary bypass surgery (CABG) is widely used in clinical practice and is one of the most studied methods of surgical intervention. This type of myocardial revascularization is considered more effective than endovascular interventions. It is known that activation of a systemic inflammatory response leads to the development of cardiovascular complications (nonfatal myocardial infarction, stroke, death). One of the most common complications in the early postoperative period after CABG is the dysfunction of coronary graft (DCG). It is assumed that activation of systemic inflammatory response plays an important role in the development of graft dysfunction both in the early and late postoperative period. The study of the pathophysiological mechanisms underlying the development of cardiovascular complications, as well as the identification of new biomarkers and therapeutic strategies for their prevention are important trends today. This article discusses the role of various markers of inflammation in the development of cardiovascular events.

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About Authors

  • Atabi Sh. Iraskhanov, Postgraduate; ORCID
  • Yuriy I. Buziashvili, Dr. Med. Sci., Professor, Academician of the RAS, Head of Department; ORCID
  • Inna.V. Koksheneva, Dr. Med. Sci., Senior Researcher; ORCID
  • Elvina F. Tugeeva, Dr. Med. Sci., Senior Researcher; ORCID
  • Tabarik R. Timerbulatova, Resident Physician; ORCID

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


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