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Dynamics of the prevalence of cardiovascular pathology, disorders of longitudinal strain and diastolic function of the left ventricle in individuals with optimal visualization on echocardiography 3 and 12 months after COVID-19 pneumonia

Authors: Krinochkin D.V., Yaroslavskaya E.I., Shirokov N.E., Gorbatenko E.A., Gultyaeva E.P., Krinochkina I.R., Korovina I.O., Osokina N.A., Migacheva A.V., Kalyuzhnaya E.N.

Company: 1 Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Tomsk, Russian Federation
2 Tyumen State Medical University, Tyumen, Russian Federation
3 Regional Clinical Hospital No. 1, Tyumen, Russian Federation

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Type:  Original articles


DOI: https://doi.org/10.24022/1997-3187-2023-17-3-375-385

For citation: Krinochkin D.V., Yaroslavskaya E.I., Shirokov N.E., Gorbatenko E.A., Gultyaeva E.P., Krinochkina I.R., Korovina I.O., Osokina N.A., Migacheva A.V., Kalyuzhnaya E.N. Dynamics of the prevalence of cardiovascular pathology, disorders of longitudinal strain and diastolic function of the left ventricle in individuals with optimal visualization on echocardiography 3 and 12 months after COVID-19 pneumonia. Creative Cardiology. 2023; 17 (3): 375–85 (in Russ.). DOI: 10.24022/1997-3187-2023-17-3-375-385

Received / Accepted:  23.08.2023 / 11.09.2023

Keywords: COVID-19 pneumonia cardiovascular disease echocardiography left ventricular longitudinal strain left ventricular diastolic function

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Abstract

Objective. To study the dynamics of cardiovascular pathology, left ventricular longitudinal strain and diastolic function in individuals with optimal visualization on echocardiography 3 and 12 months after COVID-19 pneumonia.

Material and methods. Out of 380 patients of the Prospective Registry of Survivors of COVID-19-Associated Pneumonia who underwent clinical examination 3 and 12 months after discharge, the dynamics of left ventricular global longitudinal strain (LV GLS) was studied in 206 patients with optimal visualization quality in echocardiography (54 [46; 60] years; 49.5% of women).

Results. During the observation period, the frequency of cardiovascular diseases increased by 6.7%, including arterial hypertension (AH) – by 6.2%, coronary artery disease (CAD) – by 3.9%. The mean left ventricle (LV) ejection fraction increased (68.2±4.7 vs 69.0±4.0%, p=0.026) while LV GLS did not change significantly (–19.5±2.3% and – 19.5±2.5%, p=0.962). Decreased LV GLS 12 months after COVID-19 pneumonia was observed in 27.7%. There was a decrease in parameters of LV diastolic function: the velocity of early diastolic LV filling (71.0±16.4 cm/s vs 8.0±2.5 cm/s, p=0.023) and early diastolic velocity of the septal part of the mitral annulus (8.4±3.0 versus 8.0±2.5 cm/s, p=0.023). The number of patients with heart failure with preserved ejection fraction (HFpEF) (number of points according to the HFA-PEFF algorithm ≥5) was small (3.9 and 1.5%, p=0.180), the number of persons with a low probability of HFpEF (number of points from 0 to 1) increased (from 53.9 to 65.0% p=0.004), there was a trend towards a decrease in the number of patients with suspected HFpEF (scores from 2 to 4) (42.2 vs. 33.5%, p=0.053).

Conclusion. One year after COVID-19 pneumonia, patients with optimal visualization on echocardiography show an increase in the incidence of AH and CAD, as well as a negative trend in LV diastolic function. Decreased LV GLS is present in 27.7% of patients. 33.5% of patients potentially have an initial stage of HFpEF and require a diastolic stress test.

References

  1. Petersen E.L., Goßling A., Adam G., Aepfelbacher M., Behrendt C.-A., Cavus E. et al. Multi-organ assessment in mainly non-hospitalized individuals after SARS-CoV-2 infection: the Hamburg City Health Study. Eur. Heart J. 2022; 43 (11): 1124– 37. DOI: 10.1093/eurheartj/ehab914
  2. Luis S.A., Chan J., Pellikka P.A. Echocardiographic assessment of left ventricular systolic function: an overview of contemporary techniques, including speckle-tracking echocardiography. Mayo Clin. Proc. 2019; 94 (1): 125–38. DOI: 10.1016/j.mayocp.2018.07.017
  3. Electronic database “Prospective register of persons who have had COVID-19-associated pneumonia” (certificate No. 2021622535). Yaroslavskaya E.I., Petelina T.I., Musikhina N.A., Gorbatenko E.A., Krinochkin D.V., Gultyaeva E.P., Shirokov N.E., Garanina V.D. Registered in the Database Registry on November 18, 2021.
  4. Mareev V.Yu., Fomin I.V., Ageev F.T., Begrambekova Yu.L., Vasyuk Yu.A., Garganeeva A.A. et al. Russian Heart Failure Society, Russian Society of Cardiology. Russian Scientific Medical Society of Internal Medicine Guidelines for Heart failure: chronic (CHF) and acute decompensated (ADHF). Diagnosis, prevention and treatment. Kardiologiia. 2018; 58 (6S): 8–158 (in Russ.). DOI: 10.18087/cardio.2475
  5. Kobalava Z.D., Konradi A.O., Nedogoda S.V., Shlyakhto E.V., Arutyunov G.P., Baranova E.I. Arterial hypertension in adults. Clinical guidelines 2020. Russian Journal of Cardiology. 2020; 25 (3): 3786 (in Russ.). DOI: 10.15829/1560-4071-2020-3-3786
  6. Morozov S.P., Protsenko D.N., Smetanina S.V., AndreichenkoA.E., Ambrosi O.E., Balanyuk E.A. et al. Radiation diagnosis of coronavirus disease (COVID-19): organization, methodology, interpretation of results: preprint №. TsDT – 2020 – I. Series “Best Practices in Radiation and Instrumental Diagnostics”. Moscow; 2020: 60 (in Russ.).
  7. Pieske B., Tschöpe C., de Boer R.A., Fraser A.G., Anker S.D., Donal E. et al. How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Eur. Heart J. 2019; 40 (40): 3297–17. DOI: 10.1093/eurheartj/ehz641
  8. Alcidi G.M., Esposito R., Evola V., Santoro C., Lembo M., Sorrentino R. et al. Normal reference values of multilayer longitudinal strain according to age decades in a healthy population: A single-centre experience. Eur. Heart J. Cardiovasc. Imaging. 2018; 19 (12): 1390–6. DOI: 10.1093/ehjci/jex306
  9. Lang R.M., Badano L.P., Mor-Avi V., Afilalo J., Armstrong A., Ernande L. et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J. Am. Soc. Echocardiogr. 2015; 28 (1): 1–39.e14. DOI: 10.1016/j.echo.2014.10.003
  10. Marwick T.H., Gillebert T.C., Aurigemma G., Chirinos J., Derumeaux G., Galderisi M. et al. Recommendations on the use of echocardiography in adult hypertension: a report from the European Association of Cardiovascular Imaging (EACVI) and the American Society of Echocardiography (ASE). Eur. Heart J. Cardiovasc. Imaging. 2015; 16 (6): 577–605. DOI: 10.1093/ehjci/jev076
  11. Krinochkin D.V., Yaroslavskaya E.I., Shirokov N.E., Gultyaeva E.P., Krinochkina I.R., Korovina I.O. et al. Cardiovascular status and echocardiographic changes in survivors of COVID-19 pneumonia three months after hospital discharge. Russian Journal of Cardiology. 2021; 26 (9): 4656 (in Russ.). DOI: 10.15829/1560-4071-2021-4656
  12. Shirokov N.E., Yaroslavskaya E.I., Krinochkin D.V., Osokina N.A. Dynamics of global and segmental strain as a marker of right ventricular contractility recovery in patients after COVID-19 pneumonia. Russian Journal of Cardiology. 2023; 28 (1): 5212 (in Russ.). DOI: 10.15829/1560-4071-2023-5212
  13. Chistiakova M.V., Govorin A.V., Zaitsev D.N., Kalinkina T.V., Medvedeva N.A., Kurokhtina A.A., Chistyakov R.O. Cardiohemodynamic changes and cardiac arrhythmias after coronavirus infection. Kardiologiia. 2023; 63 (2): 27–33 (in Russ.). DOI: 10.18087/cardio.2023.2.n1973
  14. Lassen M.С.H., Skaarup K.G., Nørgaard J.N., Alhakak A.S., Sengeløv M., Nielsen A.B. et al. Recovery of cardiac function following COVID-19 infection: ECHOVID-19 – a longitudinal cohort study. J. Am. Coll. Cardiol. 2021; 77 (18): 3035. DOI: 10.1016/S0735-1097(21)04390-4
  15. Ikonomidis I., Lambadiari V., Mitrakou A., Kountouri A., Katogiannis K., Thymis J. et al. Myocardial work and vascular dysfunction are partially improved at 12 months after COVID-19 infection. Eur. J. Heart Fail. 2022; 24 (4): 727–9. DOI: 10.1002/ejhf.2451
  16. Ovrebotten T., Myhre P.L., Grimsmo J., Mecinaj A., Trebinjac D., Nossen M.B. et al. Changes in cardiac structure and function from 3 to 12 months after hospitalization for COVID-19. Clin. Cardiol. 2022; 45: 1044–52. DOI: 10.1002/clc.23891
  17. Anjan V.Y., Loftus T.M., Burke M.A., Akhter N., Fonarow G.C., Gheorghiade M. et al. Prevalence, clinical phenotype, and outcomes associated with normal B-type natriuretic peptide levels in heart failure with preserved ejection fraction. Am. J. Cardiol. 2012; 110 (6): 870–6. DOI: 10.1016/j.amjcard.2012.05.014

About Authors

  • Dmitriy V. Krinochkin, Cand. Med. Sci., Senior Researcher, Head of Department; ORCID
  • Elena I. Yaroslavskaya, Dr. Med. Sci., Leading Researcher, Head of Department; ORCID
  • Nikita E. Shirokov, Cand. Med. Sci., Researcher; ORCID
  • Elena A. Gorbatenko, Research Assistant; ORCID
  • Elena P. Gultyaeva, Cand. Med. Sci., Senior Researcher, Head of Department; ORCID
  • Inna R. Krinochkina, Cand. Med. Sci., Associate Professor of Chair; ORCID
  • Irina O. Korovina, Pulmonologist; ORCID
  • Nadezhda A. Osokina, Junior Researcher; ORCID
  • Anastasiya V. Migacheva, Research Assistant; ORCID
  • Elena N. Kalyuzhnaya, Research Assistant; ORCID

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


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