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Genetic aspects of multifocal atherosclerosis

Authors: Buziashvili Yu.I., Koksheneva I.V., Timerbulatova T.R.

Company: Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russian Federation

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Type:  Reviews


DOI: https://doi.org/10.24022/1997-3187-2025-19-3-264-271

For citation: Buziashvili Yu.I., Koksheneva I.V., Timerbulatova T.R. Genetic aspects of multifocal atherosclerosis. Creative Cardiology. 2025; 19 (3): 264–271 (in Russ.). DOI: 10.24022/1997-3187-2025-19-3-264-271

Received / Accepted:  30.01.2025 / 21.07.2025

Keywords: multifocal atherosclerosis genetic variability variability of endothelial mechanosensitive receptor genes



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Abstract

The complex and multifactorial pathophysiology of multifocal atherosclerosis requires the integration of various clinical, molecular genetic, and histochemical methods to gain insights into the diverse aspects, molecular pathways, and cellular functions involved in atherogenesis.

The article reviews published studies on the genetic mechanisms of multifocal atherosclerosis. Research in the field of genetics is important for defining the biological and pathophysiological mechanisms of multifocal atherosclerosis. These approaches using high-throughput sequencing technologies and high-tech computational tools provide unprecedented opportunities not only to better understand the pathophysiology of atherosclerosis development in a holistic and integrative

manner, but also to identify new molecular and diagnostic targets for the therapy of atherosclerotic diseases. A deeper understanding of how genetic variability affects susceptibility to multifocal atherosclerosis may help in the development of new therapeutic agents for the treatment of this complex disease.

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About Authors

  • Yuriy I. Buziashvili, Dr. Med. Sci., Professor, Academician of the Russian Academy of Sciences, Head of the Clinical Diagnostic Department; ORCID
  • Inna V. Koksheneva, Dr. Med. Sci., Senior Researcher; ORCID
  • Tabarik R. Timerbulatova, Resident Physician; ORCID

Chief Editor

Elena Z. Golukhova, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, Director of Bakoulev National Medical Research Center for Cardiovascular Surgery


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