Genetic aspects of multifocal atherosclerosis
Authors:
Type: Reviews
DOI:
For citation: Buziashvili Yu.I., Koksheneva I.V., Timerbulatova T.R. Genetic aspects of multifocal atherosclerosis. Creative Cardiology. 2025; 19 (3): 264–271 (in Russ.). DOI: 10.24022/1997-3187-2025-19-3-264-271
Received / Accepted: 30.01.2025 / 21.07.2025
Keywords: multifocal atherosclerosis genetic variability variability of endothelial mechanosensitive receptor genes
Abstract
The complex and multifactorial pathophysiology of multifocal atherosclerosis requires the integration of various clinical, molecular genetic, and histochemical methods to gain insights into the diverse aspects, molecular pathways, and cellular functions involved in atherogenesis.
The article reviews published studies on the genetic mechanisms of multifocal atherosclerosis. Research in the field of genetics is important for defining the biological and pathophysiological mechanisms of multifocal atherosclerosis. These approaches using high-throughput sequencing technologies and high-tech computational tools provide unprecedented opportunities not only to better understand the pathophysiology of atherosclerosis development in a holistic and integrative
manner, but also to identify new molecular and diagnostic targets for the therapy of atherosclerotic diseases. A deeper understanding of how genetic variability affects susceptibility to multifocal atherosclerosis may help in the development of new therapeutic agents for the treatment of this complex disease.
