Gene polymorphism of SLCO1B1, associated with the developmentof statin-induced myopathy, leves of vitamin d in russian patients with hyperlipidemia

Authors: G.N. Shuev 1, D.A. Sychev 2, A.V. Grachev 3

Company: 1 I.M. Sechenov First Moscow State Medical University Ministry of Health of the Russian Federation; ul. Trubetskaya, 8, str. 2, Moscow, 119991, Russian Federation;
2 Russian Medical Academy of Postgraduate Education; ul. Barrikadnaya, 2/1, Moscow, 125993, Russian Federation;
3 Multidisciplinary Medical Holding «CM-Clinic»; ul. Priorova, 36, Moscow, 125130, Russian Federation.


DOI: https://doi.org/10.15275/kreatkard.2015.04.05

For citation: Shuev GN, Sychev DA, Grachev AV. Gene polymorphism of SLCO1B1, associated with the development of statin-induced myopathy, leves of vitamin d in russian patients with hyperlipidemia. Kreativnaya Kardiologiya. 2015; 4: 40-45 (in Russian)

Keywords: pharmacogenetics SLCO1B1 statins myopathy vitamin D

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Abstract

Statins are the most commonly prescribed medicines for treatment of hypercholesterolemia. At the same time up to 25% patients cannot tolerate or discontinue statin therapy due to statin-induced side effects. In majority of cases side-effects are attributed to SLCO1B1 gene mutation. Our research was focused on the frequency of the SLCO1B1*5 genetic variant in the Russian population.

Material and methods. 1071 patients with hyperlipidemia were included into the study. Genotypes of SLCO1B1*5 (с.521Т>С, rs4149056) were determined with polymerase chain reaction (PCR) amplification. Our data was compared to admissible data from Brazil and China. We determined the level of 25(OH)D in the blood plasma by high performance liquid chromatography in 39 patients receiving statins for 3 months or more.

Results. 665 (62%) patients had ТТ genotype of allelic variant SLCO1B1*5, 346 (32%) participants had ТС, СС variant was found in 60 patients (6%). As compared with data from Brazil and China, allele C frequency which causes an increased risk of statin-induced myopathy was found significantly more often in the Russian population. The «carrier» and «not carrier» C allele statistically significant differences in the levels of 25(OH)D was not found: 32.3±13.4 vs 40.3±10.8 nmol/l, p=0.299.

Conclusion. Pharmacogenetic testing (genotyping SLCO1B1*5) can be used in Russian patients with hyperlipidemia for calculations of maximal tolerated dose in accordance with the recommendations of ESF experts. More data are needed to assess the relationship between carriage of C allele and the level of 25(OH)D.

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Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery