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Leukocyte-platelet complexes in the pathogenesis of acute coronary syndrome. Part 1

Authors: Pinegina N.V.

Company: A.I. Evdokimov Moscow State University of Medicine and Dentistry of Ministry of Health of the Russian Federation; ulitsa Delegatskaya, 20/1, Moscow, 127473, Russian Federation

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Type:  Basic research in cardiology


DOI: https://doi.org/10.15275/kreatkard.2016.02.03

For citation: Pinegina N.V. Leukocyte-platelet complexes in the pathogenesis of acute coronary syndrome. Part 1. Kreativnaya Kardiologiya. 2016; 10 (2): 128-135 (in Russian)

Keywords: acute coronary syndrome atherosclerosis leukocyte-platelet complexes extracellular vesicles flow cytometry

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Abstract

Traditionally, the role platelets in the pathogenesis of acute coronary syndrome (ACS), is believed to be in the thrombus formation at the site of an atherosclerotic plaque rupture. Formation leukocyte-platelet complexes (LTC) can be a link between inflammation and thrombosis in the process of platelet activation in acute coronary syndrome. Although the increase in leukocyte aggregates with platelets in ACS described earlier, the contribution of complex formation in the progression of atherosclerosis and plaque destabilization is unclear. It is also unknown whether a formation is LTC is a systemic phenomenon or plays a role in the pathogenesis of in the local intracoronary inflammation in ACS. Also it is unclear whether detected in peripheral blood leukocytes aggregates are complexes with platelets or platelet-derived extracellular vesicles. This review presents the mechanisms of formation of LTC, methods for determination of leukocyte-platelet aggregates in the peripheral blood, and the impact of treatment on the formation and stability of the LTC.

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About Authors

  • Pinegina Natal'ya Viktorovna, Cardiologist, Postgraduate, Assistant

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


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