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Role of left ventricular diastolic function in ensuringthe energy tissue metabolism in patients with hypertrophiccardiomyopathy

Authors: Koloskova N.N., Kupryashov A.A., Plyushch M.G., Berseneva M.I., Bockeria L.A.

Company: A.N. Bakoulev Scientific Center for Cardiovascular Surgery of Ministry of Health of the Russian Federation; Rublevskoe shosse, 135, Moscow, 121552, Russian Federation

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Type:  Cardiomyopathy


DOI: https://doi.org/10.15275/kreatkard.2016.02.06

For citation: Koloskova N.N., Kupryashov A.A., Plyushch M.G. et al. Role of left ventricular diastolic function in ensuring the energy tissue metabolism in patients with hypertrophic cardiomyopathy. Kreativnaya Kardiologiya. 2016; 10 (2): 161-170 (in Russian)

Keywords: hypertrophic cardiomyopathy left ventricular stiffness heart failure with preserved ejection fraction diastolic function cardiopulmonary exercise testing

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Abstract

Introduction. Reduced exercise tolerance in patients with hypertrophic cardiomyopathy (HCM) is due to impaired left ventricular myocardial stiffness and diastolic heart failure.

Objective. To investigate the hemodynamic parameters, peak VO2, morpho-functional left ventricular performance, natriuretic peptide level to assess the severity of diastolic dysfunction in patients with hypertrophic cardiomyopathy.

Material and methods. The study included 25 patients (mean age 34.5±15.6 years). Patients were divided into 2 groups, based on the basal interventricular septum thickness and the LV posterior wall thickness ratio. Groups differed significantly at relative increment of end-diastolic LV pressure after Valsalva probe (1.48±0.32 in group 1 vs 1.82±0.45 in the group 2, p=0.041). Patients of the first group with slight increment observed the lowest values of oxygen consumption at rest (ρ=0.517, p=0.07).

Conclusion. It was revealed that diastolic dysfunction in patients with HCM is determined by various functional and morphological factors that can affect the physical activity of patients and prognosis of the disease to varying degree.

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About Authors

  • Koloskova Nadezhda Nikolaevna, MD, PhD, Cardiologist;
  • Kupryashov Aleksey Anatol'evich, MD, DM, Chief of Chair;
  • Plyushch Marina Grigor'evna, PhD of Biol. Sci., Chief of Laboratory;
  • Berseneva Marina Ivanovana, MD, PhD, Cardiologist, Senior Research Associate;
  • Bockeria Leo Antonovich, Academician of Russian Academy of Sciences and Russian Academy of Medical Sciences, Director of A.N. Bakoulev Scientific Center for Cardiovascular Surgery

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


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