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Leukocyte-platelet complexes in the pathogenesis of acute coronary syndrome. Part 2

Authors: Pinegina N.V.

Company: A.I. Evdokimov Moscow State University of Medicine and Dentistry of Ministry of Health of the Russian Federation; ulitsa Delegatskaya, 20, stroenie1, Moscow, 127473, Russian Federation

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DOI: https://doi.org/10.15275/kreatkard.2016.03.02

For citation: Pinegina N.V.. Leukocyte-platelet complexes in the pathogenesis of acute coronary syndrome. Part 2. Kreativnaya Kardiologiya. 2016; 10 (3): 201-209 (in Russian)

Keywords: acute coronary syndrome atherosclerosis leukocyte-platelet complexes extracellular vesicles flow cytometry

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Abstract

Traditionally, the role of platelets in the pathogenesis of acute coronary syndrome (ACS), as suggested, is the thrombus formation at the site of an atherosclerotic plaque rupture. Formation of leukocyte-platelet complexes (LTC) can be a link between inflammation and thrombosis in the process of platelet activation in ACS. Although the increase in leukocyte aggregates with platelets in ACS was described earlier, the contribution of complex formation in the progression of atherosclerosis and plaque destabilization is unclear. It is also unknown whether the formation of LTC is a systemic phenomenon or plays a role in the pathogenesis of the local intracoronary inflammation in ACS. Also it is unclear whether leukocyte aggregates detected in peripheral blood are complexes with platelets or with platelet-derived extracellular vesicles. This review presents the mechanisms of formation of LTC, methods for determination of leukocyte-platelet aggregates in the peripheral blood, and the impact of treatment on the formation and stability of the LTC.

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Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


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