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Cytomegalovirus infection in patients with acute myocardial infarction

Authors: Lebedeva А.M., Maryukhnich E.V., Аlbakova Т.M., Аlbakova R.M., Ryazankina N.B., Ryzhkova E.V.

Company: Department of Cardiology and Laboratory of Atherothrombosis of A.I. Yevdokimov Moscow State University of Medicine and Dentistry of Ministry of Health of the Russian Federation, Delegatskaya ulitsa, 20, stroenie 1, Moscow, 127473, Russian Federation

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Type:  Reviews


DOI: https://doi.org/10.24022/1997-3187-2018-12-2-159-166

For citation: Lebedeva А.M., Maryukhnich E.V., Аlbakova Т.M., Аlbakova R.M., Ryazankina N.B., Ryzhkova E.V. Cytomegalovirus infection in patients with acute myocardial infarction. Creative Cardiology. 2018; 12 (2): 159–66 (in Russ.). DOI: 10.24022/1997-3187-2018-12-2-159-166

Received / Accepted:  May 30, 2018 / June 09, 2018

Keywords: atherosclerosis acute myocardial infarction herpes virus cytomegalovirus endothelial function

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Abstract

Progression and destabilization of atherosclerotic plaque are the main causes of the development of acute myocardial infarction. In recent years, convincing evidence has been obtained that the main reason of the progression of atherosclerosis is the chronic inflammatory reaction and the activation of immune cells within the atherosclerotic plaques. However, despite their importance, the causes of this inflammation remain largely unknown. Previously, data were obtained on the role of viral and bacterial infections in atherogenesis. However, the results of the studies were extremely contradictory. Among the likely triggers of the inflammatory reaction, a special place is allocated to the human herpes viruses and, above all, cytomegalovirus, as one of the most prevalent viruses in the population with a tendency to a chronic persistence in the human body, which correlates with the chronic inflammation in atherosclerotic plaques. In this review, we consider the data obtained by us and other researchers on cytomegalovirus activation in patients with coronary artery disease.

Acknowledgements. This work was supported by Russian Scientific Foundation, agreement #18-15-00420
Conflict of interest. The authors declare no conflict of interest.

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About Authors

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


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