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Features of the pathogenesis of coronary heart disease in HIV infection

Authors: Murkamilov I.T., Aytbaev K.A., Fomin V.V., Schastlivenko A.I.

Company: 1 I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, 720020, Kyrgyzstan
2 Kyrgyz Russian Slavic University, Bishkek, 720000, Kyrgyzstan
3 Research Institute of Molecular Biology and Medicine, Bishkek, 720040, Kyrgyzstan
4 I.M. Sechenov First Moscow State Medical University, Moscow, 119991, Russian Federation
5 Vitebsk State Order of Peoples Friendship Medical University, Vitebsk, 210009, Belarus

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Type:  Reviews


DOI: https://doi.org/10.24022/1997-3187-2020-14-3-255-271

For citation: Murkamilov I.T., Aytbaev K.A., Fomin V.V., Schastlivenko A.I. Features of the pathogenesis of coronary heart disease in HIV infection. Creative Cardiology. 2020; 14 (3): 255–71 (in Russ.). DOI: 10.24022/1997-3187-2020-14-3-255-271

Received / Accepted:  01.09.2020 / 07.09.2020

Keywords: human immunodeficiency virus inflammation dyslipidemia risk factors coronary heart disease

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Abstract

There are currently 36.7 million people living with immunodeficiency viruses (HIV) worldwide. Every day more than 7 thousand people are infected with HIV and over 5.2 million people need antiretroviral therapy. Many researchers note that the HIV epidemic has already acquired a new quality – a large number of comorbid conditions and severe forms of cardiovascular diseases (CVD). The article presents data on high risk and early onset of CVD in people with HIV – infection compared to the general population. The effect on CVD genesis in HIVinfected patients is considered both of individual traditional and additional (specific) risk factors. The evidence of the contributing role of HIV infection in the occurrence of coronary heart disease is presented, including through pathogenetic mechanisms such as viral load, endothelial dysfunction, inflammation, and activation of the immune system. It was noted that correction of CVD risk factors for HIV infection, including viral load using antiretroviral therapy, reduces cardiovascular risk.

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About Authors

  • Ilkhom T. Murkamilov, Cand. Med. Sc., Acting Associate Professor, ORCID
  • Kubanych A. Aytbaev, Dr. Med. Sc., Professor, Head of Laboratory, ORCID
  • Viktor V. Fomin, Dr. Med. Sc., Professor, Corresponding Member of RAS, Chief of Chair, Vice-Rector, ORCID
  • Andrey I. Schastlivenko, Cand. Med. Sc., Associate Professor, ORCID

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


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