What is atrial fibrillation “silent” about: methods, frequency and clinical implications of its detection in asymp- tomatic patients
Authors:
Company: Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russian Federation
For correspondence: Sign in or register.
Type: Reviews
DOI:
For citation: Serguladze S.Yu., Tetvadze I.V., Pronicheva I.V. What is atrial fibrillation “silent” about: methods, frequency and clinical implications of its detection in asymptomatic patients. Creative Cardiology. 2021; 15 (3): 307–21 (in Russ.). DOI: 10.24022/1997-3187-2021-15-3-307-321
Received / Accepted: 31.03.2021 / 30.08.2021
Keywords: “silent” atrial fibrillation atrial fibrillation burden diagnosis clinical consequences thromboembolic complications
Abstract
“Silent” atrial fibrillation is an asymptomatic atrial arrhythmia that can be diagnosed incidentally by recording an electrocardiogram, external Holter, or by implanted cardiac devices. There is a substantial body of literature on “silent” atrial fibrillation, but it remains largely undiagnosed in routine clinical practice. Meanwhile, new diagnostic tools have significantly improved the detection of this subclinical asymptomatic arrhythmia, creating the potential for mass screening with new technologies and promising an important step forward in e-health. However, it is still unknown whether “silent” atrial fibrillation is associated with the same risk of thromboembolism as symptomatic, and whether these asymptomatic and often brief episodes therefore require anticoagulant therapy and rate control. The purpose of this review is to highlight the problem of detecting “silent” atrial fibrillation in a population, its clinical significance and the advisability of anticoagulation in these conditions.References
- Chugh S.S., Havmoeller R., Narayanan K., Singh D., Rienstra M., Benjamin E.J. et al. Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study. Circulation. 2014; 129 (8): 837–47. DOI: 10.1161/CIRCULATIONAHA.113.005119
- Colilla S., Crow A., Petkun W., Singer D.E., Simon T., Liu X. Estimates of current and future incidence and prevalence of atrial fibrillation in the U.S. adult population. Am. J. Cardiol. 2013; 112 (8): 1142–7. DOI: 10.1016/j.amjcard.2013.05.063
- Krijthe B.P., Kunst A., Benjamin E.J., Lip G.Y., Franco O.H., Hofman A. et al. Projections on the number of individuals with atrial fibrillation in the European Union, from 2000 to 2060. Eur. Heart J. 2013; 34 (35): 2746–51. DOI: 10.1093/eurheartj/eht280
- Romero J.R., Wolf P.A. Epidemiology of stroke: legacy of the Framingham Heart Study. Glob. Heart. 2013; 8 (1): 67–75. DOI: 10.1016/j.gheart.2012.12.007
- January C.T., Wann L.S., Calkins H., Chen L.Y., Cigarroa J.E., Cleveland J.C., Jr. et al. 2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines and the Heart Rhythm Society. J. Am. Coll. Cardiol. 2019; 74 (1): 104–32. DOI: 10.1016/j.jacc.2019.01.011
- Glotzer T.V., Daoud E.G., Wyse D.G., Singer D.E., Ezekowitz M.D., Hilker C. et al. The relationship between daily atrial tachyarrhythmia burden from implantable device diagnostics and stroke risk: the TRENDS study. Circ. Arrhythm. Electrophysiol. 2009; 2 (5): 474–80. DOI: 10.1161/CIRCEP.109.849638
- Mahajan R., Perera T., Elliott A.D., Twomey D.J., Kumar S., Munwar D.A. et al. Subclinical devicedetected atrial fibrillation and stroke risk: a systematic review and meta-analysis. Eur. Heart J. 2018; 39 (16): 1407–15. DOI: 10.1093/eurheartj/ehx731
- Kirchhof P., Benussi S., Kotecha D., Ahlsson A., Atar D., Casadei B. et al. ESC Scientific Document Group. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur. Heart J. 2016; 37 (38): 2893–962. DOI: 10.1093/eurheartj/ehw210
- Dobreanu D., Svendsen J.H., Lewalter T., Hernández-Madrid A., Lip G.Y., Blomström-Lundqvist C. et al. Scientific Initiatives Committee, European Heart Rhythm Association. Current practice for diagnosis and management of silent atrial fibrillation: results of the European Heart Rhythm Association survey. Europace. 2013; 15 (8): 1223–5. DOI: 10.1093/europace/eut227
- Hindricks G., Potpara T., Dagres N., Arbelo E., Bax J.J., Blomström-Lundqvist C. et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS). Eur. Heart J. 2020; 42 (5): 373–498. DOI: 10.1093/eurheartj/ehaa612
- Gladstone D.J., Spring M., Dorian P., Panzov V., Thorpe K.E., Hall J. et al. EMBRACE Investigators and Coordinators. Atrial fibrillation in patients with cryptogenic stroke. N. Engl. J. Med. 2014; 370 (26): 2467–77. DOI: 10.1056/NEJMoa1311376
- Shanmugam N., Boerdlein A., Proff J., Ong P., Valencia O., Maier S.K. et al. Detection of atrial high-rate events by continuous home monitoring: clinical significance in the heart failure-cardiac resynchronization therapy population. Europace. 2012; 14 (2): 230–7. DOI: 10.1093/europace/eur293
- Glotzer T.V., Hellkamp A.S., Zimmerman J., Sweeney M.O., Yee R., Marinchak R. et al. MOST Investigators. Atrial high rate episodes detected by pacemaker diagnostics predict death and stroke: report of the Atrial Diagnostics Ancillary Study of the MOde Selection Trial (MOST). Circulation. 2003; 107 (12): 1614–819. DOI: 10.1161/01.CIR.0000057981.70380.45
- Daoud E.G., Glotzer T.V., Wyse D.G., Ezekowitz M.D., Hilker C., Koehler J., Ziegler P.D; TRENDS Investigators. Temporal relationship of atrial tachyarrhythmias, cerebrovascular events, and systemic emboli based on stored device data: a subgroup analysis of TRENDS. Heart Rhythm. 2011; 8 (9): 1416–23. DOI: 10.1016/j.hrthm.2011.04.022
- Healey J.S., Connolly S.J., Gold M.R., Israel C.W., Van Gelder I.C., Capucci A. et al. ASSERT Investigators. Subclinical atrial fibrillation and the risk of stroke. N. Engl. J. Med. 2012; 366 (2): 120–9. DOI: 10.1056/NEJMoa1105575
- Healey J.S., Martin J.L., Duncan A., Connolly S.J., Ha A.H., Morillo C.A. et al. Pacemaker-detected atrial fibrillation in patients with pacemakers: prevalence, predictors, and current use of oral anticoagulation. Can. J. Cardiol. 2013; 29 (2): 224–8. DOI: 10.1016/j.cjca.2012.08.019
- Ziegler P.D., Glotzer T.V., Daoud E.G., Wyse D.G., Singer D.E., Ezekowitz M.D. et al. Incidence of newly detected atrial arrhythmias via implantable devices in patients with a history of thromboembolic events. Stroke. 2010; 41 (2): 256–60. DOI: 10.1161/STROKEAHA.109.571455
- Ziegler P.D., Glotzer T.V., Daoud E.G., Singer D.E., Ezekowitz M.D., Hoyt R.H. et al. Detection of previously undiagnosed atrial fibrillation in patients with stroke risk factors and usefulness of continuous monitoring in primary stroke prevention. Am. J. Cardiol. 2012; 110 (9): 1309–14. DOI: 10.1016/j.amjcard.2012.06.034
- Gonzalez M., Keating R.J., Markowitz S.M., Liu C.F., Thomas G., Ip J.E. et al. Newly detected atrial high rate episodes predict long-term mortality outcomes in patients with permanent pacemakers. Heart Rhythm. 2014; 11 (12): 2214–21. DOI: 10.1016/j.hrthm.2014.08.019.
- Martin D.T., Bersohn M.M., Waldo A.L., Wathen M.S., Choucair W.K., Lip G.Y. et al. IMPACT Investigators. Randomized trial of atrial arrhythmia monitoring to guide anticoagulation in patients with implanted defibrillator and cardiac resynchronization devices. Eur. Heart J. 2015; 36 (26): 1660–8. DOI: 10.1093/eurheartj/ehv115
- Benezet-Mazuecos J., Iglesias J.A., Cortes M., Vieja J.J., Rubio J.M., Sanchez-Borque P. Silent brain infarcts in high blood pressure patients with cardiac implantable electronic devices: unmasking silent atrial fibrillation. J. Hypertens. 2016; 34 (2): 338–44. DOI: 10.1097/HJH.0000000000000787
- Cotter P.E., Martin P.J., Ring L., Warburton E.A., Belham M., Pugh P.J. Incidence of atrial fibrillation detected by implantable loop recorders in unexplained stroke. Neurology. 2013; 80 (17): 1546–50. DOI: 10.1212/WNL.0b013e31828f1828
- Ritter M.A., Kochhäuser S., Duning T., Reinke F., Pott C., Dechering D.G. et al. Occult atrial fibrillation in cryptogenic stroke: detection by 7-day electrocardiogram versus implantable cardiac monitors. Stroke. 2013; 44 (5): 1449–52. DOI: 10.1161/STROKEAHA.111.676189
- Etgen T., Hochreiter M., Mundel M., Freudenberger T. Insertable cardiac event recorder in detection of atrial fibrillation after cryptogenic stroke: an audit report. Stroke. 2013; 44 (7): 2007–9. DOI: 10.1161/STROKEAHA.113.001340
- Christensen L.M., Krieger D.W., Højberg S., Pedersen O.D., Karlsen F.M., Jacobsen M.D. et al. Paroxysmal atrial fibrillation occurs often in cryptogenic ischaemic stroke. Final results from the SURPRISE study. Eur. J. Neurol. 2014; 21 (6): 884–9. DOI: 10.1111/ene.12400
- Sanna T., Diener H.C., Passman R.S., Di Lazzaro V., Bernstein R.A., Morillo C.A. et al. CRYSTAL AF Investigators. Cryptogenic stroke and underlying atrial fibrillation. N. Engl. J. Med. 2014; 370 (26): 2478–86. DOI: 10.1056/NEJMoa1313600
- Jorfida M., Antolini M., Cerrato E., Caprioli M.G., Castagno D., Garrone P. et al. Cryptogenic ischemic stroke and prevalence of asymptomatic atrial fibrillation: a prospective study. J. Cardiovasc. Med. 2016; 17 (12): 863–9. DOI: 10.2459/JCM.0000000000000181
- Poli S., Diedler J., Härtig F., Götz N., Bauer A., Sachse T. et al. Insertable cardiac monitors after cryptogenic stroke – a risk factor based approach to enhance the detection rate for paroxysmal atrial fibrillation. Eur. J. Neurol. 2016; 23 (2): 375–81. DOI: 10.1111/ene.12843
- Reiffel J.A., Verma A., Kowey P.R., Halperin J.L., Gersh B.J., Wachter R. et al. REVEAL AF Investigators. Incidence of previously undiagnosed atrial fibrillation using insertable cardiac monitors in a high-risk population: the REVEAL AF Study. JAMA Cardiol. 2017; 2 (10): 1120–7. DOI: 10.1001/jamacardio.2017.3180
- Tse H.F., Lau C.P. Prevalence and clinical implications of atrial fibrillation episodes detected by pacemaker in patients with sick sinus syndrome. Heart. 2005; 91 (3): 362–4. DOI: 10.1136/hrt.2003.027219
- Capucci A., Santini M., Padeletti L., Gulizia M., Botto G., Boriani G. et al. Italian AT500 Registry Investigators. Monitored atrial fibrillation duration predicts arterial embolic events in patients suffering from bradycardia and atrial fibrillation implanted with antitachycardia pacemakers. J. Am. Coll. Cardiol. 2005; 46 (10): 1913–20. DOI: 10.1016/j.jacc.2005.07.044
- Botto G.L., Padeletti L., Santini M., Capucci A., Gulizia M., Zolezzi F. et al. Presence and duration of atrial fibrillation detected by continuous monitoring: crucial implications for the risk of thromboembolic events. J. Cardiovasc. Electrophysiol. 2009; 20 (3): 241–8. DOI: 10.1111/j.1540-8167.2008.01320.x
- Boriani G., Glotzer T.V., Santini M., West T.M., De Melis M., Sepsi M. et al. Device-detected atrial fibrillation and risk for stroke: an analysis of >10,000 patients from the SOS AF project (Stroke preventiOn Strategies based on Atrial Fibrillation information from implanted devices). Eur. Heart J. 2014; 35 (8): 508–16. DOI: 10.1093/eurheartj/eht491
- Vinereanu D., Lopes R.D., Bahit M.C., Xavier D., Jiang J., Al-Khalidi H.R. et al. IMPACT-AF investigators. A multifaceted intervention to improve treatment with oral anticoagulants in atrial fibrillation (IMPACT-AF): an international, cluster-randomised trial. Lancet. 2017; 390 (10104): 1737–46. DOI: 10.1016/S0140-6736(17)32165-7
- Sposato L.A., Cipriano L.E., Riccio P.M., Hachinski V., Saposnik G. Very short paroxysms account for more than half of the cases of atrial fibrillation detected after stroke and TIA: a systematic review and meta-analysis. Int. J. Stroke. 2015; 10 (6): 801–7. DOI: 10.1111/ijs.12555 36. Brambatti M., Connolly S.J., Gold M.R., Morillo C.A., Capucci A., Muto C. et al. ASSERT Investigators. Temporal relationship between subclinical atrial fibrillation and embolic events. Circulation. 2014; 129 (21): 2094–9. DOI: 10.1161/CIRCULATIONAHA.113.007825
- Kennedy H.L. Silent atrial fibrillation: definition, clarification, and unanswered issues. Ann. Noninvas. Electrocardiol. 2015; 20 (6): 518–25. DOI: 10.1111/anec.12307
- Patti G., Sticchi A. Subclinical atrial fibrillation: when to give NAO? Eur. Heart J. 2020; 22 (E): E105–9. DOI: 10.1093/eurheartj/suaa072
- Boriani G., Laroche C., Diemberger I., Fantecchi E., Popescu M.I., Rasmussen L.H. et al. Asymptomatic atrial fibrillation: clinical correlates, management, and outcomes in the EORP-AF Pilot General Registry. Am. J. Med. 2015; 128 (5): 509–18.e2. DOI: 10.1016/j.amjmed.2014.11.026
- Camm A.J., Simantirakis E., Goette A., Lip G.Y., Vardas P., Calvert M. et al. Atrial high-rate episodes and stroke prevention. Europace. 2017; 19 (2): 169–79. DOI: 10.1093/europace/euw279
- Chair G.B., Bax J., Boriani G., Chen S.A., Dagres N., Glotzer T.V. et al. ESC Scientific Document Group. Device-detected subclinical atrial tachyarrhythmias: definition, implications and management-an European Heart Rhythm Association (EHRA) consensus document, endorsed by Heart Rhythm Society (HRS), Asia Pacific Heart Rhythm Society (APHRS) and Sociedad Latinoamericana de Estimulación Cardíaca y Electrofisiología (SOLEACE). Europace. 2017; 19 (9): 1556–78. DOI: 10.1093/europace/eux163
- Bockeria L.A., Shengeliya L.D. Changes in the heart with atrial fibrillation. Part I. Cardiopathy of atrial fibrillation: new dilemmas and old problems. Annaly Aritmologii (Annals of Arrhythmology). 2016; 13 (3): 138–47 (in Russ.). DOI: 10.15275/annaritmol.2016.3.2
- Mashina T.V., Golukhova E.Z. Left ventricular diastolic dysfunction in patients with atrial fibrillation: pathogenetic mechanisms and modern ultrasound estimation techniques (an analytical review). Creative Cardiology. 2014; 8 (4): 43–52 (in Russ.).
- Lopes R.D., Alings M., Connolly S.J., Beresh H., Granger C.B., Mazuecos J.B. et al. Rationale and design of the Apixaban for the Reduction of Thrombo-Embolism in Patients With Device-Detected Sub-Clinical Atrial Fibrillation (ARTESiA) trial. Am. Heart J. 2017; 189: 137–45. DOI: 10.1016/j.ahj.2017.04.008
- Bertaglia E., Blank B., Blomström-Lundqvist C., Brandes A., Cabanelas N., Dan G.A. et al. Atrial high-rate episodes: prevalence, stroke risk, implications for management, and clinical gaps in evidence. Europace. 2019; 21 (10): 1459–67. DOI: 10.1093/europace/euz172
- Passman R., Leong-Sit P., Andrei A.C., Huskin A., Tomson T.T., Bernstein R. et al. Targeted anticoagulation for atrial fibrillation guided by continuous rhythm assessment with an insertable cardiac monitor: the rhythm evaluation for anticoagulation with continuous monitoring (REACT.COM) Pilot Study. J. Cardiovasc. Electrophysiol. 2016; 27 (3): 264–70. DOI: 10.1111/jce.12864
- Diederichsen S.Z., Haugan K.J., Kronborg C., Graff C., Højberg S., Køber L. et al. Comprehensive evaluation of rhythm monitoring strategies in screening for atrial fibrillation: insights from patients at risk monitored long term with an im-plantable loop recorder. Circulation. 2020; 141 (19): 1510–22. DOI: 10.1161/CIRCULATIONAHA.119.044407