What is atrial fibrillation “silent” about: methods, frequency and clinical implications of its detection in asymp- tomatic patients

Authors: Serguladze S.Yu., Tetvadze I.V., Pronicheva I.V.

Company: Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russian Federation

For correspondence:  Sign in or register.

Type:  Reviews


DOI: https://doi.org/10.24022/1997-3187-2021-15-3-307-321

For citation: Serguladze S.Yu., Tetvadze I.V., Pronicheva I.V. What is atrial fibrillation “silent” about: methods, frequency and clinical implications of its detection in asymptomatic patients. Creative Cardiology. 2021; 15 (3): 307–21 (in Russ.). DOI: 10.24022/1997-3187-2021-15-3-307-321

Received / Accepted:  31.03.2021 / 30.08.2021

Keywords: “silent” atrial fibrillation atrial fibrillation burden diagnosis clinical consequences thromboembolic complications

Download
Full text:  

 

Abstract

“Silent” atrial fibrillation is an asymptomatic atrial arrhythmia that can be diagnosed incidentally by recording an electrocardiogram, external Holter, or by implanted cardiac devices. There is a substantial body of literature on “silent” atrial fibrillation, but it remains largely undiagnosed in routine clinical practice. Meanwhile, new diagnostic tools have significantly improved the detection of this subclinical asymptomatic arrhythmia, creating the potential for mass screening with new technologies and promising an important step forward in e-health. However, it is still unknown whether “silent” atrial fibrillation is associated with the same risk of thromboembolism as symptomatic, and whether these asymptomatic and often brief episodes therefore require anticoagulant therapy and rate control. The purpose of this review is to highlight the problem of detecting “silent” atrial fibrillation in a population, its clinical significance and the advisability of anticoagulation in these conditions.

References

  1. Chugh S.S., Havmoeller R., Narayanan K., Singh D., Rienstra M., Benjamin E.J. et al. Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study. Circulation. 2014; 129 (8): 837–47. DOI: 10.1161/CIRCULATIONAHA.113.005119
  2. Colilla S., Crow A., Petkun W., Singer D.E., Simon T., Liu X. Estimates of current and future incidence and prevalence of atrial fibrillation in the U.S. adult population. Am. J. Cardiol. 2013; 112 (8): 1142–7. DOI: 10.1016/j.amjcard.2013.05.063
  3. Krijthe B.P., Kunst A., Benjamin E.J., Lip G.Y., Franco O.H., Hofman A. et al. Projections on the number of individuals with atrial fibrillation in the European Union, from 2000 to 2060. Eur. Heart J. 2013; 34 (35): 2746–51. DOI: 10.1093/eurheartj/eht280
  4. Romero J.R., Wolf P.A. Epidemiology of stroke: legacy of the Framingham Heart Study. Glob. Heart. 2013; 8 (1): 67–75. DOI: 10.1016/j.gheart.2012.12.007
  5. January C.T., Wann L.S., Calkins H., Chen L.Y., Cigarroa J.E., Cleveland J.C., Jr. et al. 2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines and the Heart Rhythm Society. J. Am. Coll. Cardiol. 2019; 74 (1): 104–32. DOI: 10.1016/j.jacc.2019.01.011
  6. Glotzer T.V., Daoud E.G., Wyse D.G., Singer D.E., Ezekowitz M.D., Hilker C. et al. The relationship between daily atrial tachyarrhythmia burden from implantable device diagnostics and stroke risk: the TRENDS study. Circ. Arrhythm. Electrophysiol. 2009; 2 (5): 474–80. DOI: 10.1161/CIRCEP.109.849638
  7. Mahajan R., Perera T., Elliott A.D., Twomey D.J., Kumar S., Munwar D.A. et al. Subclinical devicedetected atrial fibrillation and stroke risk: a systematic review and meta-analysis. Eur. Heart J. 2018; 39 (16): 1407–15. DOI: 10.1093/eurheartj/ehx731
  8. Kirchhof P., Benussi S., Kotecha D., Ahlsson A., Atar D., Casadei B. et al. ESC Scientific Document Group. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur. Heart J. 2016; 37 (38): 2893–962. DOI: 10.1093/eurheartj/ehw210
  9. Dobreanu D., Svendsen J.H., Lewalter T., Hernández-Madrid A., Lip G.Y., Blomström-Lundqvist C. et al. Scientific Initiatives Committee, European Heart Rhythm Association. Current practice for diagnosis and management of silent atrial fibrillation: results of the European Heart Rhythm Association survey. Europace. 2013; 15 (8): 1223–5. DOI: 10.1093/europace/eut227
  10. Hindricks G., Potpara T., Dagres N., Arbelo E., Bax J.J., Blomström-Lundqvist C. et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS). Eur. Heart J. 2020; 42 (5): 373–498. DOI: 10.1093/eurheartj/ehaa612
  11. Gladstone D.J., Spring M., Dorian P., Panzov V., Thorpe K.E., Hall J. et al. EMBRACE Investigators and Coordinators. Atrial fibrillation in patients with cryptogenic stroke. N. Engl. J. Med. 2014; 370 (26): 2467–77. DOI: 10.1056/NEJMoa1311376
  12. Shanmugam N., Boerdlein A., Proff J., Ong P., Valencia O., Maier S.K. et al. Detection of atrial high-rate events by continuous home monitoring: clinical significance in the heart failure-cardiac resynchronization therapy population. Europace. 2012; 14 (2): 230–7. DOI: 10.1093/europace/eur293
  13. Glotzer T.V., Hellkamp A.S., Zimmerman J., Sweeney M.O., Yee R., Marinchak R. et al. MOST Investigators. Atrial high rate episodes detected by pacemaker diagnostics predict death and stroke: report of the Atrial Diagnostics Ancillary Study of the MOde Selection Trial (MOST). Circulation. 2003; 107 (12): 1614–819. DOI: 10.1161/01.CIR.0000057981.70380.45
  14. Daoud E.G., Glotzer T.V., Wyse D.G., Ezekowitz M.D., Hilker C., Koehler J., Ziegler P.D; TRENDS Investigators. Temporal relationship of atrial tachyarrhythmias, cerebrovascular events, and systemic emboli based on stored device data: a subgroup analysis of TRENDS. Heart Rhythm. 2011; 8 (9): 1416–23. DOI: 10.1016/j.hrthm.2011.04.022
  15. Healey J.S., Connolly S.J., Gold M.R., Israel C.W., Van Gelder I.C., Capucci A. et al. ASSERT Investigators. Subclinical atrial fibrillation and the risk of stroke. N. Engl. J. Med. 2012; 366 (2): 120–9. DOI: 10.1056/NEJMoa1105575
  16. Healey J.S., Martin J.L., Duncan A., Connolly S.J., Ha A.H., Morillo C.A. et al. Pacemaker-detected atrial fibrillation in patients with pacemakers: prevalence, predictors, and current use of oral anticoagulation. Can. J. Cardiol. 2013; 29 (2): 224–8. DOI: 10.1016/j.cjca.2012.08.019
  17. Ziegler P.D., Glotzer T.V., Daoud E.G., Wyse D.G., Singer D.E., Ezekowitz M.D. et al. Incidence of newly detected atrial arrhythmias via implantable devices in patients with a history of thromboembolic events. Stroke. 2010; 41 (2): 256–60. DOI: 10.1161/STROKEAHA.109.571455
  18. Ziegler P.D., Glotzer T.V., Daoud E.G., Singer D.E., Ezekowitz M.D., Hoyt R.H. et al. Detection of previously undiagnosed atrial fibrillation in patients with stroke risk factors and usefulness of continuous monitoring in primary stroke prevention. Am. J. Cardiol. 2012; 110 (9): 1309–14. DOI: 10.1016/j.amjcard.2012.06.034
  19. Gonzalez M., Keating R.J., Markowitz S.M., Liu C.F., Thomas G., Ip J.E. et al. Newly detected atrial high rate episodes predict long-term mortality outcomes in patients with permanent pacemakers. Heart Rhythm. 2014; 11 (12): 2214–21. DOI: 10.1016/j.hrthm.2014.08.019.
  20. Martin D.T., Bersohn M.M., Waldo A.L., Wathen M.S., Choucair W.K., Lip G.Y. et al. IMPACT Investigators. Randomized trial of atrial arrhythmia monitoring to guide anticoagulation in patients with implanted defibrillator and cardiac resynchronization devices. Eur. Heart J. 2015; 36 (26): 1660–8. DOI: 10.1093/eurheartj/ehv115
  21. Benezet-Mazuecos J., Iglesias J.A., Cortes M., Vieja J.J., Rubio J.M., Sanchez-Borque P. Silent brain infarcts in high blood pressure patients with cardiac implantable electronic devices: unmasking silent atrial fibrillation. J. Hypertens. 2016; 34 (2): 338–44. DOI: 10.1097/HJH.0000000000000787
  22. Cotter P.E., Martin P.J., Ring L., Warburton E.A., Belham M., Pugh P.J. Incidence of atrial fibrillation detected by implantable loop recorders in unexplained stroke. Neurology. 2013; 80 (17): 1546–50. DOI: 10.1212/WNL.0b013e31828f1828
  23. Ritter M.A., Kochhäuser S., Duning T., Reinke F., Pott C., Dechering D.G. et al. Occult atrial fibrillation in cryptogenic stroke: detection by 7-day electrocardiogram versus implantable cardiac monitors. Stroke. 2013; 44 (5): 1449–52. DOI: 10.1161/STROKEAHA.111.676189
  24. Etgen T., Hochreiter M., Mundel M., Freudenberger T. Insertable cardiac event recorder in detection of atrial fibrillation after cryptogenic stroke: an audit report. Stroke. 2013; 44 (7): 2007–9. DOI: 10.1161/STROKEAHA.113.001340
  25. Christensen L.M., Krieger D.W., Højberg S., Pedersen O.D., Karlsen F.M., Jacobsen M.D. et al. Paroxysmal atrial fibrillation occurs often in cryptogenic ischaemic stroke. Final results from the SURPRISE study. Eur. J. Neurol. 2014; 21 (6): 884–9. DOI: 10.1111/ene.12400
  26. Sanna T., Diener H.C., Passman R.S., Di Lazzaro V., Bernstein R.A., Morillo C.A. et al. CRYSTAL AF Investigators. Cryptogenic stroke and underlying atrial fibrillation. N. Engl. J. Med. 2014; 370 (26): 2478–86. DOI: 10.1056/NEJMoa1313600
  27. Jorfida M., Antolini M., Cerrato E., Caprioli M.G., Castagno D., Garrone P. et al. Cryptogenic ischemic stroke and prevalence of asymptomatic atrial fibrillation: a prospective study. J. Cardiovasc. Med. 2016; 17 (12): 863–9. DOI: 10.2459/JCM.0000000000000181
  28. Poli S., Diedler J., Härtig F., Götz N., Bauer A., Sachse T. et al. Insertable cardiac monitors after cryptogenic stroke – a risk factor based approach to enhance the detection rate for paroxysmal atrial fibrillation. Eur. J. Neurol. 2016; 23 (2): 375–81. DOI: 10.1111/ene.12843
  29. Reiffel J.A., Verma A., Kowey P.R., Halperin J.L., Gersh B.J., Wachter R. et al. REVEAL AF Investigators. Incidence of previously undiagnosed atrial fibrillation using insertable cardiac monitors in a high-risk population: the REVEAL AF Study. JAMA Cardiol. 2017; 2 (10): 1120–7. DOI: 10.1001/jamacardio.2017.3180
  30. Tse H.F., Lau C.P. Prevalence and clinical implications of atrial fibrillation episodes detected by pacemaker in patients with sick sinus syndrome. Heart. 2005; 91 (3): 362–4. DOI: 10.1136/hrt.2003.027219
  31. Capucci A., Santini M., Padeletti L., Gulizia M., Botto G., Boriani G. et al. Italian AT500 Registry Investigators. Monitored atrial fibrillation duration predicts arterial embolic events in patients suffering from bradycardia and atrial fibrillation implanted with antitachycardia pacemakers. J. Am. Coll. Cardiol. 2005; 46 (10): 1913–20. DOI: 10.1016/j.jacc.2005.07.044
  32. Botto G.L., Padeletti L., Santini M., Capucci A., Gulizia M., Zolezzi F. et al. Presence and duration of atrial fibrillation detected by continuous monitoring: crucial implications for the risk of thromboembolic events. J. Cardiovasc. Electrophysiol. 2009; 20 (3): 241–8. DOI: 10.1111/j.1540-8167.2008.01320.x
  33. Boriani G., Glotzer T.V., Santini M., West T.M., De Melis M., Sepsi M. et al. Device-detected atrial fibrillation and risk for stroke: an analysis of >10,000 patients from the SOS AF project (Stroke preventiOn Strategies based on Atrial Fibrillation information from implanted devices). Eur. Heart J. 2014; 35 (8): 508–16. DOI: 10.1093/eurheartj/eht491
  34. Vinereanu D., Lopes R.D., Bahit M.C., Xavier D., Jiang J., Al-Khalidi H.R. et al. IMPACT-AF investigators. A multifaceted intervention to improve treatment with oral anticoagulants in atrial fibrillation (IMPACT-AF): an international, cluster-randomised trial. Lancet. 2017; 390 (10104): 1737–46. DOI: 10.1016/S0140-6736(17)32165-7
  35. Sposato L.A., Cipriano L.E., Riccio P.M., Hachinski V., Saposnik G. Very short paroxysms account for more than half of the cases of atrial fibrillation detected after stroke and TIA: a systematic review and meta-analysis. Int. J. Stroke. 2015; 10 (6): 801–7. DOI: 10.1111/ijs.12555 36. Brambatti M., Connolly S.J., Gold M.R., Morillo C.A., Capucci A., Muto C. et al. ASSERT Investigators. Temporal relationship between subclinical atrial fibrillation and embolic events. Circulation. 2014; 129 (21): 2094–9. DOI: 10.1161/CIRCULATIONAHA.113.007825
  36. Kennedy H.L. Silent atrial fibrillation: definition, clarification, and unanswered issues. Ann. Noninvas. Electrocardiol. 2015; 20 (6): 518–25. DOI: 10.1111/anec.12307
  37. Patti G., Sticchi A. Subclinical atrial fibrillation: when to give NAO? Eur. Heart J. 2020; 22 (E): E105–9. DOI: 10.1093/eurheartj/suaa072
  38. Boriani G., Laroche C., Diemberger I., Fantecchi E., Popescu M.I., Rasmussen L.H. et al. Asymptomatic atrial fibrillation: clinical correlates, management, and outcomes in the EORP-AF Pilot General Registry. Am. J. Med. 2015; 128 (5): 509–18.e2. DOI: 10.1016/j.amjmed.2014.11.026
  39. Camm A.J., Simantirakis E., Goette A., Lip G.Y., Vardas P., Calvert M. et al. Atrial high-rate episodes and stroke prevention. Europace. 2017; 19 (2): 169–79. DOI: 10.1093/europace/euw279
  40. Chair G.B., Bax J., Boriani G., Chen S.A., Dagres N., Glotzer T.V. et al. ESC Scientific Document Group. Device-detected subclinical atrial tachyarrhythmias: definition, implications and management-an European Heart Rhythm Association (EHRA) consensus document, endorsed by Heart Rhythm Society (HRS), Asia Pacific Heart Rhythm Society (APHRS) and Sociedad Latinoamericana de Estimulación Cardíaca y Electrofisiología (SOLEACE). Europace. 2017; 19 (9): 1556–78. DOI: 10.1093/europace/eux163
  41. Bockeria L.A., Shengeliya L.D. Changes in the heart with atrial fibrillation. Part I. Cardiopathy of atrial fibrillation: new dilemmas and old problems. Annaly Aritmologii (Annals of Arrhythmology). 2016; 13 (3): 138–47 (in Russ.). DOI: 10.15275/annaritmol.2016.3.2
  42. Mashina T.V., Golukhova E.Z. Left ventricular diastolic dysfunction in patients with atrial fibrillation: pathogenetic mechanisms and modern ultrasound estimation techniques (an analytical review). Creative Cardiology. 2014; 8 (4): 43–52 (in Russ.).
  43. Lopes R.D., Alings M., Connolly S.J., Beresh H., Granger C.B., Mazuecos J.B. et al. Rationale and design of the Apixaban for the Reduction of Thrombo-Embolism in Patients With Device-Detected Sub-Clinical Atrial Fibrillation (ARTESiA) trial. Am. Heart J. 2017; 189: 137–45. DOI: 10.1016/j.ahj.2017.04.008
  44. Bertaglia E., Blank B., Blomström-Lundqvist C., Brandes A., Cabanelas N., Dan G.A. et al. Atrial high-rate episodes: prevalence, stroke risk, implications for management, and clinical gaps in evidence. Europace. 2019; 21 (10): 1459–67. DOI: 10.1093/europace/euz172
  45. Passman R., Leong-Sit P., Andrei A.C., Huskin A., Tomson T.T., Bernstein R. et al. Targeted anticoagulation for atrial fibrillation guided by continuous rhythm assessment with an insertable cardiac monitor: the rhythm evaluation for anticoagulation with continuous monitoring (REACT.COM) Pilot Study. J. Cardiovasc. Electrophysiol. 2016; 27 (3): 264–70. DOI: 10.1111/jce.12864
  46. Diederichsen S.Z., Haugan K.J., Kronborg C., Graff C., Højberg S., Køber L. et al. Comprehensive evaluation of rhythm monitoring strategies in screening for atrial fibrillation: insights from patients at risk monitored long term with an im-plantable loop recorder. Circulation. 2020; 141 (19): 1510–22. DOI: 10.1161/CIRCULATIONAHA.119.044407

About Authors

  • Sergey Yu. Serguladze, Dr. Med. Sci., Professor, Chief of Department, Cardiac Surgeon; ORCID
  • Inga V. Tetvadze, Cand. Med. Sci., Senior Researcher, Chief Physician of V.I. Bourakovsky Institute of Cardiac Surgery; ORCID
  • Irina V. Pronicheva, Cand. Med. Sci., Senior Researcher, Cardiologist; ORCID

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery