Magnetic-resonance myocardium mappingin hypertrophic cardiomyopathy associatedwith atrial fibrillation

Authors: Dariy O.Yu., Aleksandrova S.A., Malenkov D.A., Bereznitskiy V.S., Yurpol’skaya L.A., Makarenko V.N., Bockeria L.A.

Company: Bakoulev National Medical Research Center for Cardiovascular Surgery of Ministry of Health of the Russian Federation, Rublevskoe shosse, 135, Moscow, 121552, Russian Federation

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Type:  Original articles


DOI: https://doi.org/10.24022/1997-3187-2018-12-4-328-340

For citation: Dariy O.Yu., Aleksandrova S.A., Malenkov D.A., Bereznitskiy V.S., Yurpol’skaya L.A., Makarenko V.N., Bockeria L.A. Magnetic-resonance myocardium mapping in hypertrophic cardiomyopathy associated with atrial fibrillation. Creative Cardiology. 2018; 12 (4): 328–40 (in Russ.). DOI: 10.24022/1997-3187-2018-12-4-328-340

Received / Accepted:  09.11.2018/12.11.2018

Keywords: magnetic resonance imaging hypertrophic cardiomyopathy atrial fibrillation Т1-map

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Abstract

Objective. To identify magnetic resonance (MR) predictors associated with atrial fibrillation (AF) in patients with hypertrophic cardiomyopathy (HCM).

Material and methods. We performed 30 cardiac magnetic resonance studies on Achieva TX 3T scanner at 2 groups of patients. The 1st (n=16) group included patients with HCM and AF and 2d group (n=14) – HCM without AF. Modified Look-Locker Inversion Recovery (MOLLI) T1 maps and late-enhancement (LGE) images were obtained for interatrial septum (IAS) and 3 short axis slices of left ventricle. Statistical analysis was performed using Spearman’s Rank correlation coefficient.

Results. Mean native IAS myocardial T1 values at 1st group patient was around 1649±135 ms, significantly higher versus the 2d group – 1343±203 ms (p<0,05). We obtained the shortness of the post-contrast IAS myocardium T1 at 1st group patients (341±40 ms), versus to 2d – 363±58 ms (p<0,05). ECV IAS at 1st group patients was 57,9±7%, at 2d – 62,3±8%. The correlation of AF and native T1 had been found statistically significant (r=0,679, p<0,05). High positive correlation of AF and left atrium (LA) volume r=0,739, p<0,05. There was weak correlation of AF from ECV (r=0,18, p<0,05). ROC-analyze gave a good model of native IAS myocardial T1 and LA volume for assume AF development at patients with HCM: AUC=0,806±0,104, cut-off 1410 ms and AUC=0,879±0,070, cut-off point 78,78 ml respectively.

Conclusions. Our study established the increase of IAS T1 relaxation time at patients with HCM and AF. There was no significant difference in the ECV in patient groups. Availability AF depends on native T1 mean and LA volume and is independent of ECV.

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About Authors

  • Ol’ga Yu. Dariy, Radiologist, orcid.org/0000-0003-0140-8166;
  • Svetlana A. Aleksandrova, Cand. Med. Sc., Senior Researcher, orcid.org/0000-0002-7795-9709;
  • Dmitriy A. Malenkov, Cardiovascular Surgeon, Junior Researcher, orcid.org/0000-0003-4656-0209;
  • Vladimir S. Bereznitskiy, Junior Researcher, orcid.org/0000-0003-1942-5749;
  • Lyudmila A. Yurpol’skaya, Dr Med. Sc., Leading Researcher, orcid.org/0000-0001-7780-2405;
  • Vladimir N. Makarenko, Dr Med. Sc., Professor, Head of Department, orcid.org/0000-0002-8700-7592;
  • Leo A. Bockeria, Academician of Russian Academy of Sciences and Russian Academy of Medical Sciences, Director, orcid.org/0000-0002-6180-2619

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery