Global deformation of left ventricle: chemotherapy-induced cardiotoxicity

Authors: Akildzhonov F.R., Buziashvili Yu.I., Asymbekova E.U., Artamonova E.V., Tugeeva E.F.

Company: 1 Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russian Federation
2 National Medical Research Center of Oncology named after N.N. Blokhin, Moscow, Russian Federation

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Type:  Reviews


For citation: Akildzhonov F.R., Buziashvili Yu.I., Asymbekova E.U., Artamonova E.V., Tugeeva E.F. Global deformation of left ventricle: chemotherapy-induced cardiotoxicity. Creative Cardiology. 2022; 16 (1): 15–25 (in Russ.). DOI: 10.24022/1997-3187-2022-16-1-15-25

Received / Accepted:  20.10.2021 / 28.03.2022

Keywords: cardiotoxicity global longitudinal strain of left ventricle trastuzumab

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The achievements of targeted therapy of oncological diseases over the past decades has significantly increased the survival rate of patients who verified malignant neoplasm. It is known that some chemotherapeutic agents (for example, anthracycles, trastuzumab), commonly used in the treatment of malignant neoplasms, have a cardiotoxic effect. One of the most unfavorable side effects is the development of early left ventricular dysfunction (LV) and the progression of heart failure. Global longitudinal strain (GLS) of the left ventricle reveals early subclinical dysfunction of myocardial LV and can be used in patients receiving chemotherapy. The prognostic value of the GLS assessment to identify cardiotoxicity associated with chemotherapy is poorly studied. Progress in the treatment of cancer over the past decades has improved long-term survival of patients, but increased the frequency of cardiotoxicity. In this review, we summarize the existing literature on the global deformation of the myocardium of the left ventricle in the longitudinal direction (GLS) and represent the current aspects of the pathogenesis of cardiotoxicity in patients receiving chemotherapy


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About Authors

  • Firdavsdzhon R. Akildzhonov, Postgraduate; ORCID
  • Yuriy I. Buziashvili, Dr. Med. Sci., Professor, Academician of RAS, Head of Department, ORCID
  • El’mira U. Asymbekova, Dr. Med. Sci., Leading Researcher; ORCID
  • Elena V. Artamonova, Dr. Med. Sci., Leading Researcher; ORCID
  • E’lvina F. Tugeeva, Dr. Med. Sci., Senior Researcher, ORCID

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery