Obesity and COVID-19 – a double blow to the heart

Authors: Lifanova L.S., Gromova O.I.

Company: Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russian Federation

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Type:  Reviews

DOI: https://doi.org/10.24022/1997-3187-2022-16-3-289-301

For citation: Lifanova L.S., Gromova O.I. Obesity and COVID-19 – a double blow to the heart. Creative Cardiology.2022; 16 (3): 289–301 (in Russ.). DOI: 10.24022/1997-3187-2022-16-3-289-301

Received / Accepted:  28.07.2022 / 05.09.2022

Keywords: COVID-19 SARS-CoV-2 obesity cardiovascular disease

Full text:  



Obesity is one of the main severe COVID-19 risk factors. SARS-CoV-2 causes endothelitis that lead to inflammation and prothrombotic state. Also visceral adipose tissue is a source of different prothrombogenic and proinflammatory cytokines that make prognosis and survival of patients with COVID-19 worse. The synergy of the COVID-19 and obesity pandemics is a double blow to health, especially in young patients. Weight loss due to lifestyle modifications and vaccination are effective methods of the severe COVID-19 prevention in obese patients. This review presents the main pathogenetic aspects of cardiovascular disease development and progression in obese patients with COVID-19 and possible methods of adverse outcomes prevention in this group of patients.


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About Authors

  • Lubov’ S. Lifanova, Cardiologist, Research; ORCID
  • Ol’ga I. Gromova, Cand. Med. Sci., Researcher; ORCID

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery