Complications after coronary artery bypass grafting – focus on genetic predictors (acute respiratory distress syndrome, acute kidney injury, neurological complications, atrial fibrillation)

Authors: Abramovskikh O.S., Belov D.V., Zotova M.A., Fokin A.A., Lukin O.P.

Company: 1 South Ural State Medical University, Chelyabinsk, Russian Federation
2 Federal Center for Cardiovascular Surgery, Chelyabinsk, Russian Federation

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Type:  Reviews


DOI: https://doi.org/10.24022/1997-3187-2023-17-2-217-226

For citation: Abramovskikh O.S., Belov D.V., Zotova M.A., Fokin A.A., Lukin O.P. Complications after coronary artery bypassgrafting – focus on genetic predictors (acute respiratory distress syndrome, acute kidney injury, neurological complications, atrial fibrillation). Creative Cardiology. 2023; 17 (2): 217–26 (in Russ.). DOI: 10.24022/1997-3187-2023-17-2-217-226

Received / Accepted:  17.04.2023 / 02.05.2023

Keywords: cardiac surgery complications genetic predictors cardiopulmonary bypass



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Abstract

The purpose of the review article is to present literature data on the role of genetic predictors of complications after cardiac surgery under cardiopulmonary bypass. Scientific publications were searched, including the PubMed, RSCI databases and the Google Scholar search engine, as well as references. Articles relevant to the purpose of the review were selected for the period from 1996 to 2022. Polymorphisms of two candidate genes APOA1 and IL-18 showed an association with the development of acute respiratory distress syndrome after heart surgery. The risk of neurological disorders after heart surgery has a genetic basis, including both polymorphic markers of individual genes (PAI-1) and intergenic interactions (CRP and IL-6). Evaluation of the genetic predisposition to postoperative acute kidney injury, as well as the survival of patients after heart surgery, showed a strong association of these conditions with a group of polymorphic markers: GRM7/LMCD1-AS1 and rs10262995 in BBS9, the CATT7 allele of the MIF gene, the LL genotype of the HMOX1 gene. Currently, the significance of genetic variability of the GRK5, NEURL, CAND2 genes, the T allele of Lys198Asn of the ET-1 gene has been shown in the development of acute kidney injury. As technological advances and cost reductions in nextgeneration sequencing technologies pave the way for greater availability of genomic testing, the introduction of genetic predisposition data will help improve risk stratification and reduce morbidity after cardiac surgery.

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About Authors

  • Olga S. Abramovskikh, Dr. Med. Sci., Associate Professor, Chief of Chair; ORCID
  • Dmitriy V. Belov, Cand. Med. Sci., Associate Professor of Department of Hospital Surgery of SUSMU, Cardiovascular Surgeon FCCS; ORCID
  • Mariya A. Zotova, Cand. Biol. Sci., Senior Researcher; ORCID
  • Aleksey A. Fokin, Dr. Med. Sci., Professor, Chief of Chair; ORCID
  • Oleg P. Lukin, Dr. Med. Sci., Professor of Department of Hospital Surgery of SUSMU, Chief Physician FCCS, ORCID

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery