Platelet chemiluminescence and endothelial dysfunctionin patients with acute myocardial infarction

Authors: Ryzhkova E.V.1, Ryazankina N.B.1, Lebedeva А.M.1, Аlbakova Т.M.1, Аlbakova R.M.1, Gabbasov Z.A.2, Kogan-Yasnyy V.V.3, Shpektor А.V.1, Vasilieva Е.Yu.1

Company: 1Department of Cardiology of Moscow State University of Medicine and Dentistry named after A.I. Evdokimov of Ministry of Health of the Russian Federation; Delegatskaya ulitsa, 20, stroenie 1, Moscow, 127473, Russian Federation;
2Research Institute of Clinical Cardiology of Russian Cardiology Research and Production Complex of Ministry of Health of the Russian Federation; ulitsa 3-ya Cherepkovskaya, 15a, Moscow, 121552, Russian Federation;
3
Independent researcher

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DOI: https://doi.org/10.15275/kreatkard.2016.03.01

For citation: Ryzhkova E.V., Ryazankina N.B., Lebedeva А.M., Аlbakova Т.M., Аlbakova R.M., Gabbasov Z.A., Kogan-Yasnyy V.V., Shpektor А.V., Vasilieva Е.Yu.. Platelet chemiluminescence and endothelial dysfunction in patients with acute myocardial infarction. Kreativnaya Kardiologiya. 2016; 10 (3): 195-200 (in Russian)

Keywords: platelets chemiluminescence endothelial dysfunction myocardial infarction

Полнотекстовая версия:  

 

Abstract

Objective. Previously it was demonstrated that in patients with coronary artery disease (CAD) platelets are potent  reactive oxygen species (ROS) producers. Luminol-enhanced chemiluminescence (LEC) can detect ROS generated  by platelets. The aim of this study was to evaluate endothelial function and platelets' ROS production in acute  myocardial infarction (AMI).

Material and methods. 50 AMI patients and 18 patients without CAD were enrolled in the study. In patients we measured luminol-enhanced chemiluminescence (LEC). Endothelial function was assessed by means of flowmediated dilation (FMD) test. The plasma level of the high-sensitivity C-reactive protein (hsCRP) was estimated as the marker of systemic inflammation.

Results. In AMI patients on the first day of admission we found a moderate negative correlation between levels of LEC and FMD (Spearman ρ = –0,44; р = 0,001). In patients without CAD, no significant correlations between levels of LEC, FMD, and hsCRP were revealed.

Conclusions. In our study we showed that in AMI patients on the first day of admission ROS production by platelets as evaluated from LEC is associated with severity of endothelial dysfunction.

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Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, Director of Bakoulev National Medical Research Center for Cardiovascular Surgery