Лабораторная диагностика активности ренин-ангиотензин-альдостероновой системы

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Abstract

Renin-angiotensin-aldosterone system (RAAS) has an exclusive value in the regulation of many parameters of the cardiovascular system and kidney function, including maintaining of blood pressure and water-salt metabolism. The activity of RAAS in the circulation depends on the plasma renin activity mainly, which is considered as a main regulator of the system. Synthesis of angiotensin II is a cascade of reactions: the conversion of angiotensinogen to angiotenzin I, and then under the effect of renin and angiotensin-converting enzyme, angiotensin I is transformed to angiotensin II. The evaluation of the renin-angiotensin-aldosterone system can be determined by assessments of its components. This article describes the most often used methods for the evaluation the components of RAAS.

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Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery