Эффективность реперфузионной терапии в зависимости от сроков ее проведения у больных с острым инфарктом миокарда с подъемом сегмента ST

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Abstract

The aim of the present study was to estimate the efficacy of primary percutaneous coronary intervention (PPCI) and thrombolytic therapy (TL) for ST elevated myocardial infarction (STEMI) in different time intervals after symptom onset. We enrolled 525 patients with STEMI within first 12 h after onset. All patients were divided into 3 subgroups (0-3 h, 3-6 h, and 6-12 h after symptom onset). The primary end-point was in-hospital mortality, and secondary end-points were: in-hospital death/reinfarction (combined end-point), and angina. Patients within first 3 h of symptom onset had no difference in mortality and reinfarction rate whether treated by TL or PPCI. TL over 3 h after symptom onset was associated with increased combined end-point rate (in-hospital mortality/reinfarction). Postinfarction angina was seen more often in TL group in any time intervals in comparison with patients treated with PPCI.

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Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, Director of Bakoulev National Medical Research Center for Cardiovascular Surgery