Кардиомиопатия такотсубо (часть 1)
Abstract
Takotsubo cardiomyopathy (TSCM) is a rare type of cardiomyopathy in which reversible disorders of myocardium contractility are seen. The basic feature of a syndrome is transient dyskinesia of left ventricular apex without significant coronary artery stenoses in coronary angiography. In the first lecture we studied epidemiology and early theories of pathogenesis for Takotsubo cardiomyopathy. It is shown in series of papers that patients with TSCM have spasm of coronary arteries and left ventricular outflow tract. Due to the fact that TSCM is mostly developed after stress with increase level of catecholamines in blood, its pathogenesis also refers to toxic effect of catecholamines on myocardium.References
1. Akashi Y. J., Musha H., Kida K. et al. Reversible ventricular dysfunction takotsubo cardiomyopathy // Eur. J. Heart Fail. 2005. Vol. 7. P. 1171–1176.2. Akashi Y. J., Nakazawa K., Sakakibara M. et al. 123I–MIBG myocardial scintigraphy in patients with ≪takotsubo≫ cardiomyopathy // J. Nucl. Med. 2004. Vol. 45. P. 1121–1127.
3. Aronov D. M. Takotsubo cardiomyopathy: origin and variants // Kardiologia. 2008. Vol. 48. P. 51–55.
4. Babu G. J., Bhupathy P., Petrashevskaya N. N. et al. Targeted overexpression of sarcolipin in the mouse heart decreases sarcoplasmic reticulum calcium transport and cardiac contractility // J. Biol. Chem. 2006. Vol. 281. P. 3972–3979.
5. Boluyt M. O., Long X., Eschenhagen T. et al. Isoproterenol infusion induces alterations in expression of hypertrophy-associated genes in rat heart // Am. J. Physiol. 1995. Vol. 269. P. H638–647.
6. Bybee K. A., Kara T., Prasad A. et al. Systematic review: transient left ventricular apical ballooning: a syndrome that mimics ST-segment elevation myocardial infarction // Ann. Intern. Med. 2004. Vol. 141. P. 858–865.
7. Christiaens L., Duplantier C., Allal J. et al. Normal coronary angiogram and dobutamine-induced left ventricular obstruction during stress echocardiography: a higher hemodynamic responsiveness to dobutamine // Echocardiography. 2001. Vol. 18. P. 285–290.
8. Donohue D., Movahed M. R. Clinical characteristics, demographics and prognosis of transient left ventricular apical ballooning syndrome // Heart Fail. Rev. 2005. Vol. 10. P. 311–316.
9. Dote K., Sato H., Tateishi H. et al. Myocardial stunning due to simultaneous multivessel coronary spasms: a review of 5 cases // J. Cardiol. 1991. Vol. 21. P. 203–214.
10. El Mahmoud R., Mansencal N., Pilliere R. et al. Prevalence and characteristics of left ventricular outflow tract obstruction in Tako-Tsubo syndrome // Am. Heart J. 2008. Vol. 156. P. 543–548.
11. Facciorusso A., Vigna C., Amico C. et al. Prevalence of Tako-Tsubo syndrome among patients with suspicion of acute coronary syndrome referred to our centre // Int. J. Cardiol. 2009. Vol. 134. P. 255–259.
12. Galiuto L., De Caterina A. R., Porfidia A. et al. Reversible coronary microvascular dysfunction: a common pathogenetic mechanism in Apical Ballooning or Tako-Tsubo syndrome // Eur. Heart J. 2010. Vol. 31. P. 1319–1327.
13. Goldstein D. S., Eisenhofer G., Kopin I. J. Sources and significance of plasma levels of catechols and their metabolites in humans // J. Pharmacol. Exp. Ther. 2003. Vol. 305. P. 800–811.
14. Hertting K., Krause K., Harle T. et al. Transient left ventricular apical ballooning in a community hospital in Germany // Int. J. Cardiol. 2006. Vol. 112. P. 282–288.
15. Heubach J. F., Ravens U., Kaumann A. J. Epinephrine activates both Gs and Gi pathways, but norepinephrine activates only the Gs pathway through human beta2-adrenoceptors overexpressed in mouse heart // Mol. Pharmacol. 2004. Vol. 65. P. 1313–1322.
16. Hurst R. T., Askew J. W., Reuss C. S. et al. Transient midventricular ballooning syndrome: a new variant // J. Am. Coll. Cardiol. 2006. Vol. 48. P. 579–583.
17. Ibanez B., Navarro F., Farre J. et al. Tako-tsubo syndrome associated with a long course of the left anterior descending coronary artery along the apical diaphragmatic surface of the left ventricle // Rev. Esp. Cardiol. 2004. Vol. 57. P. 209–216.
18. Izumi Y., Okatani H., Shiota M. et al. Effects of metoprolol on epinephrine-induced takotsubo-like left ventricular dysfunction in non-human primates // Hypertens. Res. 2009. Vol. 32. P. 339–346.
19. Kawai S., Kitabatake A., Tomoike H. Guidelines for diagnosis of takotsubo (ampulla) cardiomyopathy // Circ. J. 2007. Vol. 71. P. 990–992.
20. Khullar M., Datta B. N., Wahi P. L. et al. Catecholamine-induced experimental cardiomyopathy – a histopathological, histochemical and ultrastructural study // Indian Heart J. 1989. Vol. 41. P. 307–313.
21. Kim S., Yu A., Filippone L. A. et al. Inverted- Takotsubo pattern cardiomyopathy secondary to pheochromocytoma: a clinical case and literature review // Clin. Cardiol. 2010. Vol. 33. P. 200–205.
22. Kloner R. A., Bolli R., Marban E. et al. Medical and cellular implications of stunning, hibernation, and preconditioning: an NHLBI workshop // Circulation. 1998. Vol. 97. P. 1848–1867.
23. Krishnan U., Zacharzewski A., Schmitt M. Nonapical tako-tsubo cardiomyopathy associated with coronary slow flow: a case report and review of the literature // Clin. Cardiol. 2009. Vol. 32. P. E63–66.
24. Kume T., Kawamoto T., Okura H. et al. Local release of catecholamines from the hearts of patients with tako-tsubo-like left ventricular dysfunction // Circ. J. 2008. Vol. 72. P. 106–108.
25. Kushikata T., Hashimoto H., Hashiba E. et al. Case in which landiolol hydrochloride improved left ventricular outflow tract obstruction with systolic anterior motion of the mitral valve following mitral valve plasty // Masui. 2006. Vol. 55. P. 96–99.
26. Litvinov I. V., Kotowycz M. A., Wassmann S. Iatrogenic epinephrine-induced reverse Takotsubo cardiomyopathy: direct evidence supporting the role of catecholamines in the pathophysiology of the "broken heart syndrome" // Clin. Res. Cardiol. 2009. Vol. 98. P. 457–462.
27. Looi J. L., Gabriel R., Khan A. et al. Left ventricular morphology and response to beta-adrenergic stimulation in apical ballooning syndrome // Eur. J. Echocardiogr. 2011.
28. Lyon A. R., Rees P. S., Prasad S. et al. Stress (Takotsubo) cardiomyopathy – a novel pathophysiological hypothesis to explain catecholamine- induced acute myocardial stunning // Nat. Clin. Pract. Cardiovasc. Med. 2008. Vol. 5. P. 22–29.
29. Makaryus A. N., Meraj P., Rosman D. Dynamic left ventricular outflow tract obstruction induced by dobutamine stress echocardiography leading to myocardial ischemia and infarction // Int. J. Cardiovasc. Imaging. 2006. Vol. 22. P. 763–769.
30. Meimoun P., Malaquin D., Sayah S. et al. The coronary flow reserve is transiently impaired in takotsubo cardiomyopathy: a prospective study using serial Doppler transthoracic echocardiography // J. Am. Soc. Echocardiogr. 2008. Vol. 21. P. 72–77.
31. Movahed A., Reeves W. C., Mehta P. M. et al. Norepinephrine-induced left ventricular dysfunction in anesthetized and conscious, sedated dogs // Int. J. Cardiol. 1994. Vol. 45. P. 23–33.
32. Nef H. M., Mollmann H., Akashi Y. J. et al. Mechanisms of stress (Takotsubo) cardiomyopathy // Nat. Rev. Cardiol. 2010. Vol. 7. P. 187–193.
33. Neil-Dwyer G., Walter P., Cruickshank J. M. et al. Effect of propranolol and phentolamine on myocardial necrosis after subarachnoid haemorrhage // Br. Med. J. 1978. Vol. 2. P. 990–992.
34. Ohtsuka T., Hamada M., Kodama K. et al. Images in cardiovascular medicine. Neurogenic stunned myocardium // Circulation. 2000. Vol. 101. P. 2122–2124.
35. Palla A. R., Dande A. S., Petrini J. et al. Pretreatment with low-dose beta-adrenergic antagonist therapy does not affect severity of Takotsubo cardiomyopathy // Clin. Cardiol. 2012.
36. Pessoa P. M., Xavier S. S., Lima S. L. et al. Assessment of takotsubo (ampulla) cardiomyopathy using iodine-123 metaiodobenzylguanidine scintigraphy // Acta Radiol. 2006. Vol. 47. P. 1029–1035.
37. Prasad A., Madhavan M., Chareonthaitawee P. Cardiac sympathetic activity in stress-induced (Takotsubo) cardiomyopathy // Nat. Rev. Cardiol. 2009. Vol. 6. P. 430–434.
38. Previtali M., Repetto A., Scuteri L. Dobutamine induced severe midventricular obstruction and mitral regurgitation in left ventricular apical ballooning syndrome // Heart. 2005. Vol. 91. P. 353.
39. Proietti R., Rognoni A., Ardizzone F. et al. Atypical Takotsubo syndrome during anagrelide therapy // J. Cardiovasc. Med. (Hagerstown). 2009. Vol. 10. P. 546–549.
40. Sakamoto H., Nishimura H., Imataka K. et al. Abnormal Q wave, ST-segment elevation, T-wave inversion, and widespread focal myocytolysis associated with subarachnoid hemorrhage // Jpn Circ. J. 1996. Vol. 60. P. 254–257.
41. Satoh H., Tateishi H., Uchida T. et al. Takotsubotype cardiomyopathy due to multivessel spasm // Clinical Aspect of Myocardial Injury: From Ischemia to Heart Failure (in Japanese). 1990. Vol. P. 56–64.
42. Schneider B., Athanasiadis A., Stollberger C. et al. Gender differences in the manifestation of takotsubo cardiomyopathy // Int. J. Cardiol. 2011.
43. Singal P. K., Kapur N., Dhillon K. S. et al. Role of free radicals in catecholamine-induced cardiomyo- pathy // Can. J. Physiol. Pharmacol. 1982. Vol. 60. P. 1390–1397.
44. To A. C., Kay P., Khan A. A. et al. Coronary artery anatomy and apical sparing in apical ballooning syndrome: implications for diagnosis and aetiology // Heart Lung. Circ. 2010. Vol. 19. P. 219–224.
45. Tsuchihashi K., Ueshima K., Uchida T. et al. Transient left ventricular apical ballooning without coronary artery stenosis: a novel heart syndrome mimicking acute myocardial infarction. Angina Pectoris-Myocardial Infarction Investigations in Japan // J. Am. Coll. Cardiol. 2001. Vol. 38. P. 11–18.
46. Ueda T., Mizushige K., Yukiiri K. et al. Hypotension and functional left ventricular obstruction during dobutamine stress echocardiography – two case reports // Angiology. 2001. Vol. 52. P. 489–492.
47. Ueyama T., Kasamatsu K., Hano T. et al. Emotional stress induces transient left ventricular hypocontraction in the rat via activation of cardiac adrenoceptors: a possible animal model of 'tako-tsubo' cardiomyopathy // Circ. J. 2002. Vol. 66. P. 712–713.
48. Wilkenfeld C., Cohen M., Lansman S. L. et al. Heart transplantation for end-stage cardiomyopathy caused by an occult pheochromocytoma // J. Heart Lung. Transplant. 1992. Vol. 11. P. 363–366.
49. Wittstein I. S., Thiemann D. R., Lima J. A. et al. Neurohumoral features of myocardial stunning due to sudden emotional stress // N. Engl. J. Med. 2005. Vol. 352. P. 539–548.
50. Yang J. H., Park S. W., Cho S. W. et al. Dynamic left ventricular outflow tract obstruction without basal septal hypertrophy, caused by catecholamine therapy and volume depletion // Korean J. Intern. Med. 2008. Vol. 23. P. 106–109.
