Platelet phenotype in myocardial infarction

Authors: Z.A. Gabbasov 1, E.V. Ryzhkova 2

Company: 1 - Russian Cardiology Research-and-Production Complex, Ministry of Health of the RF;
2 - A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of the RF,

For citation: Gabbasov Z.A., Ryzhkova E.V. Platelet phenotype in myocardial infarction. Kreativnaya kardiologiya. 2014; 2: 48-59.

Keywords: myocardial infarction atherosclerosis platelet phenotype

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Coronary artery occlusion due to thrombosis is the main cause of myocardial infarction. Thrombus consists of fibrin and blood cells. It is known that in the initiation of clot formation mainly take part activated platelets, which further are stabilized with fibrin. Formation of occluding thrombus is dependent on platelet adhesion and platelet rate response to vessel wall damage. This review is focused on membrane phenotype of platelets in pathogenesis of myocardial infarction. We paid attention to quantitative and qualitative characteristics of surface protein composition of membranes, which are important to thrombosis, inflammation and wound healing. We focused on glycoprotein (GP) receptors (GPIb, GP VI, integrin αIIbβ3), procoagulant proteins, etc. In conclusion we overview several recent studies, devoted to predictive value of membrane-associated proteins for acute coronary syndromes and high-risk patients identification.


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Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery