Is there “obesity paradox” in coronary surgery? Effect of body mass index on hospital outcomes and three-year survival after coronary artery bypass grafting

Authors: Golukhova E.Z., Keren M.A., Volkovskaya I.V., YakhyaevaK.B., Zavalikhina T.V., Avakova S.A., Sigaev I.Yu., Alshibaya M.D., Merzlyakov V.Yu.

Company: Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russian Federation

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Type:  Original articles


DOI: https://doi.org/10.24022/1997-3187-2023-17-2-247-255

For citation: Golukhova E.Z., Keren M.A., Volkovskaya I.V., Yakhyaeva K.B., Zavalikhina T.V., Avakova S.A., Sigaev I.Yu., Alshibaya M.D., Merzlyakov V.Yu. Is there “obesity paradox” in coronary surgery? Effect of body mass index on hospital outcomes and three-year survival after coronary artery bypass grafting. Creative Cardiology. 2023; 17 (2): 247–55 (in Russ.). DOI: 10.24022/1997-3187-2023-17-2-247-255

Received / Accepted:  17.04.2023 / 02.05.2023

Keywords: coronary artery bypass grafting obesity body mass index

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Abstract

Objective. Evaluation of the effect of obesity calculated by body mass index (BMI) on hospital outcomes and three-year survival after coronary artery bypass grafting of coronary heart disease patient.

Material and methods. The study included 2239 patients with coronary artery disease who underwent elective coronary artery bypass grafting (CABG) from 2018 to 2021. The observation groups were formed depending on BMI: the main group – patients with a BMI ≥30 kg/m2 (n=902); the control group – patients with BMI <30 kg/m2 (n=1337). The study was conducted in stages: stage 1 (retrospective) – analysis of intrahospital complications: mortality, frequency of myocardial infarction, stroke, acute heart failure, renal failure, multiple organ failure, bleeding and infectious complications; stage 2 (prospective) – the frequency of death from any causes and death from cardiovascular complications for a period of 3 years after CABG.

Results. The retrospective analysis showed that the group of patients with BMI ≥30 kg/m2 compared with patients with BMI <30 kg/m2 had lower mortality (0.7% and 1.8%, in the groups, respectively, p=0.023) and a lower rate of cumulative complications (death, myocardial infarction, stroke) (1.8% and 3.1%, in groups, respectively, p=0.046). However, in the group of patients with BMI ≥30 kg/m2 in comparison with the control group, there was an increase in the incidence of infectious complications (p=0.001). There were no significant differences between the groups with regard to the frequency of other hospital complications. The prospective analysis revealed no significant differences in all-cause mortality (p=0.862) and mortality from cardiovascular diseases (p=0.917) between the groups depending on BMI.

Conclusion. In patients with coronary heart disease with MI ≥30 kg/m2 after CABG, there is a decrease in the frequency of hospital death and multicomponent point (death, myocardial infarction, stroke) and an increase in the frequency of infectious complications. The three-year overall and cardiovascular survival in patients with coronary heart disease who underwent CABG did not differ depending on BMI.

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About Authors

  • Elena Z. Golukhova, Dr. Med. Sci., Professor, Academician of RAS, Director; ORCID
  • Milena A. Keren, Dr. Med. Sci., Senior Researcher; ORCID
  • Irina V. Volkovskaya, Cand. Med. Sci., Head of Department; ORCID
  • Kumushdzhan B. Yakhyaeva, Cardiologist, Junior Researcher; ORCID
  • Tatyana V. Zavalikhina, Cand. Med. Sci., Deputy Chief Physician; ORCID
  • Susanna A. Avakova, Cand. Med. Sci., Head of Department; ORCID
  • Igor Yu. Sigaev, Dr. Med. Sci., Professor, Head of Department; ORCID
  • Mikhail D. Alshibaya, Dr. Med. Sci., Professor, Head of Department; ORCID
  • Vadim Yu. Merzlyakov, Dr. Med. Sci., Professor, Head of Department; ORCID

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery