Mortality and quality of life of the long-term outcomes after coronary artery bypass grafting in patients with acute coronary syndrome
Authors:
Company:
1 Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russian Federation
2Karshi Branch Republican Specialized Scientific and Practical Medical Center of Cardiology. Karshi, Uzbekistan
3 Russian Medical Academy of Continuing Professional Education, Moscow, Russian Federation
For correspondence: Sign in or register.
Type: Original articles
DOI:
For citation: Zhalilov A.K., Merzlyakov V.Yu., Berdibekov B.Sh., Klyuchnikov I.V., Skopin A.I., Salomov M.A., Mamedova S.K. Mortality and quality of life of the long-term outcomes after coronary artery bypass grafting in patients with acute coronary syndrome. Creative Cardiology. 2025; 19 (4): 445–458 (in Russ.). DOI: 10.24022/1997-3187-2025-19-4-445-458
Received / Accepted: 08.09.2025 / 05.11.2025
Keywords: coronary artery bypass surgery acute coronary syndrome myocardial infarction off-pump coronary artery bypass quality of life
Abstract
Objective. Comparative assessment of the risk of mortality from all causes and quality of life (QOL) in the long-term outcomes after conventional on-pump coronary artery bypass (ONCAB) and off-pump (OPCAB) in patients with acute coronary syndrome (ACS).
Material and methods. We retrospectively analyzed a consecutive series of 220 patients who underwent off-pump coronary artery bypass (CCAB) and 187 patients who underwent off-pump coronary artery bypass (OPCAB) for ACS. The average age of the patients was 62.3±9.2 years, mainly men 316 (77.6%). Propensity score matching (1:1) was applied to adjust for differences in baseline clinical and angiographic characteristics, yielding a total of 262 matched patients with ACS. The primary endpoint was all-cause mortality, the secondary endpoint included QOL in the long-term outcomes. The median follow-up period was 44.0 [28.0–54.0] months.
Results. There were no significant differences between the off-pump group and the on-pump group in the rate of the all-cause mortality (7.0 and 8.7%, respectively; hazard ratio with off-pump coronary artery bypass (CABG), 0,88; 95% confidence interval (CI), 0.41 to 1.91; p=0.75). In multivariate analysis, age and lower left ventricular ejection fraction (LVEF) were independent predictors of late mortality. Based on the data obtained, no statistically significant differences were found in individual QOL categories (physical functioning, pain intensity, physical role functioning, general health, mental health, social functioning, role functioning, and life activity) in the long-term follow-up period depending on the coronary artery bypass grafting technique (p>0.05 for all categories).
Conclusion. We did not find statistically significant differences in all-cause mortality or in individual categories of QOL in patients with ACS in the long-term follow-up after surgical myocardial revascularization depending on the technique of coronary artery bypass grafting on the beating heart or under CPB conditions.
About Authors
- Adkham K. Zhalilov, Cand. Med. Sci., Applicant, Cardiovascular Surgeon; ORCID
- Vadim Yu. Merzlyakov, Dr. Med. Sci., Head of Department, Cardiovascular Surgeon; ORCID
- Bektur Sh. Berdibekov, Cand. Med. Sci., Senior Researcher, Cardiologist; ORCID
- Ivan V. Klyuchnikov, Dr. Med. Sci., Professor, Chief Researcher, Cardiologist; ORCID
- Anton I. Skopin, Cand. Med. Sci., Cardiovascular Surgeon; ORCID
- Makhmadsharif A. Salomov, Researcher, Cardiovascular Surgeon; ORCID
- Sevindzh K. Mamedova, Cand. Med. Sci., Researcher, Cardiologist; ORCID
