The relationship of standard echocardiographic parameters with the severity of interstitial myocardial fibrosis in patients with coronary artery disease and aortic stenosis
Authors:
Company:
1 Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russian Federation
2 National Medical Research Center of Endocrinology named after Academician I.I. Dedov, Moscow, Russian Federation
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Type: Original articles
DOI:
For citation: Khugaev G.A., Berdibekov B.Sh., Kabisova A.K., Golukhova E.Z., Urusova L.S. The relationship of standard echocardiographic parameters with the severity of interstitial myocardial fibrosis in patients with coronary artery disease and aortic stenosis. Creative Cardiology. 2026; 20 (1): 106–114 (in Russ.). DOI: 10.24022/1997-3187-2026-20-1-106-114
Received / Accepted: 22.01.2026 / 04.03.2026
Keywords: interstitial myocardial fibrosis coronary artery disease aortic stenosis echocardiography final diastolic volume
Abstract
Objective. To analyze the relationship between standard echocardiographic parameters (terminal diastolic volume, terminal systolic volume, and left ventricular ejection fraction) and the severity of interstitial fibrosis.
Material and methods. The study included 114 patients with coronary artery disease, aortic stenosis and their combination, as well as a control group of 31 people. The methodology included macroscopic assessment of myocardial samples, histological examination, morphometric analysis, and statistical data processing.
Results. The main results showed significant differences in heart mass and thickness of the posterior wall of the left ventricle between the groups. In patients with aortic stenosis, a direct correlation was found between the final diastolic volume and the final systolic volume with the specific area of the interstitium. In the group with a combination of coronary heart disease and aortic stenosis, a moderate relationship was found between the final diastolic volume and the specific area of the interstitium.
Conclusion. The study confirmed the ability of echocardiography to reflect the physical characteristics of myocardial tissue and identify signs of remodeling associated with myocardial fibrosis. The final diastolic volume index can serve as a marker of the severity of myocardial fibrosis.
About Authors
- Georgiy A. Khugaev, Junior Researcher, Lecturer of the Chair of Cardiovascular Surgery with a Course in Arrhythmology and Clinical Electrophysiology, Pathologist; ORCID
- Bektur Sh. Berdibekov, Cand. Med. Sci., Senior Researcher, Cardiologist; ORCID
- Agunda K. Kabisova, Junior Researcher, Cardiologist; ORCID
- Elena Z. Golukhova, Dr. Med. Sci., Professor, Academician of RAS, Director; ORCID
- Liliya S. Urusova, Dr. Med. Sci., Head of the Department of Fundamental Pathomorphology; ORCID
