Register
Forgot your password?

The relationship of standard echocardiographic parameters with the severity of interstitial myocardial fibrosis in patients with coronary artery disease and aortic stenosis

Authors: Mamalyga M.L., Alshibaya M.D., Volkovskaya I.V., Medzhidova Z.T.

Company: 1 Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russian Federation
2 National Medical Research Center of Endocrinology named after Academician I.I. Dedov, Moscow, Russian Federation

For correspondence:  Sign in or register.

Type:  Original articles


DOI: https://doi.org/10.24022/1997-3187-2026-20-1-106-114

For citation: Khugaev G.A., Berdibekov B.Sh., Kabisova A.K., Golukhova E.Z., Urusova L.S. The relationship of standard echocardiographic parameters with the severity of interstitial myocardial fibrosis in patients with coronary artery disease and aortic stenosis. Creative Cardiology. 2026; 20 (1): 106–114 (in Russ.). DOI: 10.24022/1997-3187-2026-20-1-106-114

Received / Accepted:  22.01.2026 / 04.03.2026

Keywords: interstitial myocardial fibrosis coronary artery disease aortic stenosis echocardiography final diastolic volume



Subscribe 🔒

 

Abstract

Objective. To analyze the relationship between standard echocardiographic parameters (terminal diastolic volume, terminal systolic volume, and left ventricular ejection fraction) and the severity of interstitial fibrosis.

Material and methods. The study included 114 patients with coronary artery disease, aortic stenosis and their combination, as well as a control group of 31 people. The methodology included macroscopic assessment of myocardial samples, histological examination, morphometric analysis, and statistical data processing.

Results. The main results showed significant differences in heart mass and thickness of the posterior wall of the left ventricle between the groups. In patients with aortic stenosis, a direct correlation was found between the final diastolic volume and the final systolic volume with the specific area of the interstitium. In the group with a combination of coronary heart disease and aortic stenosis, a moderate relationship was found between the final diastolic volume and the specific area of the interstitium.

Conclusion. The study confirmed the ability of echocardiography to reflect the physical characteristics of myocardial tissue and identify signs of remodeling associated with myocardial fibrosis. The final diastolic volume index can serve as a marker of the severity of myocardial fibrosis.

References

  1. Frangogiannis N.G., Kovacic J.C. Extracellular matrix in ischemic heart disease, Part 4/4. JACC Focus Seminar. J. Am. Coll. Cardiol. 2020; 75 (17): 2219–2235. DOI: 10.1016/j.jacc.2020.03.020
  2. Golukhova E.Z. Report on the scientific and clinical activity of Bakoulev National Medical Research Center for Cardiovascular Surgery for 2022 and development prospects. The Bulletin of Bakoulev Center. Cardiovascular Diseases. 2023; 24 (Special Issue): 5–121 (in Russ.). DOI: 10.24022/1810-0694-2023-24S
  3. Canty J., Weil B. Interstitial fibrosis and diastolic dysfunction in aortic stenosis. J. Am. Coll. Cardiol. Basic. Trans. Science. 2020; 5 (5): 481–483. DOI: 10.1016/j.jacbts.2020.03.014
  4. Golukhova E.Z. Report on the clinical and scientific activity of Bakoulev National Medical Research Center for Cardiovascular Surgery for 2024. Development prospects. The Bulletin of Bakoulev Center. Cardiovascular Diseases. 2025; 26 (Special Issue): 5–130 (in Russ.). DOI: 10.24022/1810-0694-2025-26S
  5. Sonaglioni A., Lombardo M., Baravelli M. et al. Exercise stress echocardiography with tissue Doppler imaging in risk stratification of mild to moderate aortic stenosis. Int. J. Cardiovasc. Imaging. 2015; 31: 1519–1527. DOI: 10.1007/s10554-015-0724-9
  6. Kremneva L.V., Gapon L.I., Shalaev S.V. The role of soluble ST2 as a marker of fibrosis in the diagnosis and prognosis of heart failure. Creative Cardiology. 2025; 19 (2): 155–161 (in Russ.). DOI: 10.24022/1997-3187-2025-19-2-155-161
  7. Ito T., Suwa M. Echocardiographic tissue imaging evaluation of myocardial characteristics and function in cardiomyopathies. Heart Fail. Rev. 2021; 26: 813–828. DOI: 10.1007/s10741-020-09918-y
  8. Ciulla M., Paliotti R., Hess D.B. et al. Echocardiographic patterns of myocardial fibrosis in hypertensive patients: endomyocardial biopsy versus ultrasonic tissue characterization. J. Am. Soc. Echocardiogr. 1997; 10 (6): 657–664. DOI: 10.1016/S0894-7317(97)70028-2
  9. Kobalava Zh.D., Kotovskaya Yu.V., Safarova A.F., Moiseev V.S. Echocardiographic assessment of myocardial fibrosis in young men with arterial hypertension and different types of left ventricular remodeling. Kardiologiia. 2011; 51 (2): 34–39 (in Russ.).
  10. Fedorova N.V., German A.I., Kokov A.N. et al. Echocardiographic correlates of cardiac fibrosis in patients with myocardial infarction and preserved left ventricular ejection fraction. Fundamental and Clinical Medicine. 2019; 4 (2): 17–27 (in Russ.). DOI: 10.23946/2500-0764-2019-4-2-17-27
  11. Balčiūnaitė G., Besusparis J., Palionis D. et al. Exploring myocardial fibrosis in severe aortic stenosis: echo, CMR and histology data from FIB-AS study. Int. J. Cardiovasc. Imaging. 2022; 38: 1555–1568. DOI: 10.1007/s10554-022-02543-w
  12. Golukhova E.Z., Slivneva I.V., Kozlova O.S. et al. Treatment strategies for chronic coronary heart disease with left ventricular systolic dysfunction or preserved ejection fraction – a systematic review and meta-analysis. Pathophysiology. 2023; 30 (4): 640–658.

About Authors

  • Georgiy A. Khugaev, Junior Researcher, Lecturer of the Chair of Cardiovascular Surgery with a Course in Arrhythmology and Clinical Electrophysiology, Pathologist; ORCID
  • Bektur Sh. Berdibekov, Cand. Med. Sci., Senior Researcher, Cardiologist; ORCID
  • Agunda K. Kabisova, Junior Researcher, Cardiologist; ORCID
  • Elena Z. Golukhova, Dr. Med. Sci., Professor, Academician of RAS, Director; ORCID
  • Liliya S. Urusova, Dr. Med. Sci., Head of the Department of Fundamental Pathomorphology; ORCID

Chief Editor

Elena Z. Golukhova, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, Director of Bakoulev National Medical Research Center for Cardiovascular Surgery


Sort by