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Immediate and long-term treatment results for patients with coronary heart disease and chronic heart failure with reduced left ventricular ejection fraction depending on the completeness of myocardial revascularization using percutaneous coronary interventions

Authors: Sokolova N.Yu.1 2, Makhauri A.D.2, Khisimikova M.E2., Veselov S.V.2, Martynova K.A.2

Company: 1 City Clinical Hospital No. 6, Tver, Russian Federation
2 Tver State Medical University, Tver, Russian Federation

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Type:  Original articles


DOI: https://doi.org/10.24022/1997-3187-2026-20-2-234-243

For citation: Sokolova N.Yu., Makhauri A.D., Khisimikova M.E., Veselov S.V., Martynova K.A. Immediate and long-term treatment results for patients with coronary heart disease and chronic heart failure with reduced left ventricular ejection fraction depending on the completeness of myocardial revascularization using percutaneous coronary interventions. Creative Cardiology. 2026; 20 (2): 234–243 (in Russ.). DOI: 10.24022/1997-3187-2026-20-2-234-243

Received / Accepted:  06.04.2026 / 17.04.2026

Keywords: chronic ischemic heart disease heart failure left ventricular systolic dysfunction percutaneous coronary interventions complete percutaneous coronary intervention procedure chronic total occlusions



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Abstract

The aim. Comparative analysis of short-term and long-term results of PCI in patients with chronic coronary artery disease and heart failure with reduced LVEF ≤ 40% depending on the completeness of revascularization.

Material and methods. A single-center, prospective, observational, non-randomized study included 89 patients with chronic coronary artery disease and heart failure with reduced LVEF ≤ 40%, who underwent myocardial revascularization using PCI against the background of OMT. The mean age of patients was 71.2 ± 8.0 years. All patients were divided into 2 groups: complete revascularization (n = 51) and incomplete (n = 38). The groups were comparable in terms of clinical presentation, structural and functional state, and optimal drug therapy.

The primary endpoints of the study were procedural success of CTO recanalization, hospitalization for heart failure within 24 months, cardiovascular mortality, and the incidence of nonfatal myocardial infarction (MI) within 24 months.

Results. There were no differences in early complications between the study groups. Procedural failure occurred in 3 cases. In the complete revascularization group, there was a significant increase in freedom from cardiovascular (CV) death compared with incomplete revascularization after PCI (1.96% vs. 13.2%, respectively, p = 0.04), the incidence of nonfatal MI within 24 months was comparable ((n = 2, 3.9%) vs. (n = 5, 13.2%), p = 0.129), the incidence of hospitalizations due to CHF decompensation was comparable ((n = 4, 7.8%) vs. incomplete PCI (n = 6, 15.8%), respectively, p = 0.243).

Conclusion. Incomplete revascularization was associated with a higher incidence of CTO. Thus, the results of complete PCI in patients with chronic coronary artery disease and CHF with reduced LV systolic function are associated with a reduction in CV death.

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About Authors

  • Natal’ya Yu. Sokolova, Dr. Med. Sci., Associate Professor, Chief Physician1, Chief of Chair of Preventive Medicine and Medical Information Systems2; ORCID
  • Anzor D. Makhauri, Postgraduate; ORCID
  • Maryam E. Khisimikova, Postgraduate; ORCID
  • Sergey V. Veselov, Cand. Med. Sci., Associate Professor; ORCID
  • Ksenia A. Martynova, Postgraduate; ORCID

Chief Editor

Elena Z. Golukhova, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, Director of Bakoulev National Medical Research Center for Cardiovascular Surgery


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