Антикоагулянтные клиники: зарубежный опыт и перспективы для российского здравоохранения
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2. Anderson, R. Cost analysis of a managed care decentralized outpatient pharmacy anticoagulation service / R. Anderson // J. Managed Care Pharm. – 2004. – Vol. 10. – P. 159–165.
3. Ansell, J. Managing oral anticoagulant therapy / J. Ansell, J. Hirsh, J. Dalen et al. // Chest. – 2001. – Vol. 119. – P. 22–38.
4. Ansell, J. The anticoagulation guidelines task force. Consensus guidelines for coordinated outpatient oral anticoagulation therapy management / J. Ansell, M. Buttaro, O. Thomas // Ann. Pharmacother. – 1997. – Vol. 31. – P. 604–615.
5. Anticoagulants in the Secondary Prevention of Events in Coronary Thrombosis (ASPECT) Research Group. Effect of long-term oral anticoagulant treatment on mortality and cardiovascular morbidity after myocardial infarction // Lancet. – 1994. – Vol. 343. – P. 499–503.
6. Berrettini, M. Anticoagulation clinics: the Italian experience / M. Berrettini // Haematologica. – 1997. – Vol. 82. – P. 713–717.
7. Berrettini, M. Management of oral anticoagulant therapy in Italy / M. Berrettini, G. Agnelli // Seminars in thrombosis and hemostasis. – 1999. – Vol. 25, № 1. – P. 27–31.
8. Beyth, R. Prospective evaluation of an index for predicting the risk of major bleeding in outpatients treated with warfarin / R. Beyth, L. Quinn, S. Landefeld // Am. J. Med. – 1998. –Vol. 105. – P. 91–99.
9. Bond, C. Pharmacist-provided anticoagulation management in United States hospitals: death rates, length of stay, Medicare charges, bleeding complications, and transfusions / C. Bond, C. Raehl // Pharmacotherapy. – 2004. – Vol. 24. – P. 953–963.
10. Breukink-Engbers, W. Monitoring therapy with anticoagulants in the Netherlands / W. Breukink- Engbers // Seminars in thrombosis and hemostasis. – 1999. – Vol. 25. – P. 37–42.
11. Briggs, A. The development and performance validation of a tool to assess patient anticoagulation knowledge / A. Briggs, T. Jackson, S. Bruce // Research in Social & Administrative Pharmacy. – 2005. – Vol. 1. – P. 40–59.
12. Chamberlain, M. Comparison of anticoagulation clinic patient outcomes with outcomes from traditional care in a family medicine clinic / M. Chamberlain, N. Sageser, D. Ruiz // J. Am. Board Family Pract. – 2001. – Vol. 14. – P. 16–21.
13. Chiquette, E. Comparison of an anticoagulation clinic with usual medical care: anticoagulation control, patient outcomes, and health care costs / E. Chiquette, M. Amato, H. Bussey // Arch. Internal. Med. – 1998. – Vol. 158. – P. 1641–1647.
14. Conte, R. Nine-year experience with a pharmacistmanaged anticoagulation clinic / R. Conte, W. Kehoe, N. Nielson // Am. J. Hosp. Pharm. – 1986. – Vol. 43. – P. 2460–2464.
15. Dager, W. Optimization of inpatient warfarin therapy: impact of daily consultation by a pharmacistmanaged anticoagulation service / W. Dager, J. Branch, J. King // Ann. Pharmacother. – 2000. – Vol. 34. – P. 567–572.
16. Denas, G. Effectiveness and safety of a management protocol to correct over-anticoagulation with oral vitamin K: a retrospective study of 1,043 cases / G. Denas, F. Marzot, P. Offelli // J. Thromb. Thrombolysis. – 2008. – Vol. 82. – P. 168–171.
17. Ederhy, S. Strategies for primary and secondary stroke prevention in atrial fibrillation. 2006 / S. Ederhy, A. Cohen // Expert Opinion on Pharmacotherapy. – 2008. – Vol. 66. – P. 327–333.
18. Ernst, M. Evaluation of 4 years of clinical pharmacist anticoagulation case management in a rural, private physician office / M. Ernst, K. Brandt // J. Am. Pharmac. Ass. – 2003. – Vol. 43. – P. 630–636.
19. Farnsworth, F. Centralized, pharmacist-managed anticoagulation service for a university-based health system / F. Farnsworth, K. Kim, M. Jacobs // Am. J. Health-system Pharm. – 2001. – Vol. 58. – P. 77–78.
20. Francavilla, C. Registered nurse-managed anticoagulation clinic: improving patient outcomes / C. Francavilla // Nursing Economic. – 2008. – Vol. 26. – P. 130–132.
21. Franke, A. Improving anticoagulation therapy using point-of-care testing and a standardized protocol / A. Franke, M. J. Dickerson, P. Carek // Ann. Fam. Med. – 2008. – Vol. 6. – P. 28–32.
22. Gadisseur, A. Patient self-management of oral anticoagulant care vs. management by specialized anticoagulation clinics: positive effects on quality of life / A. Gadisseur, A. Kaptein // J. Thromb. Haemost. – 2004. – Vol. 2, № 4. – P. 584–591.
23. Glitter, M. J. Bleeding and thromboembolism during anticoagulant therapy: a population-based study in Rochester, Minnesota / M. J. Glitter, T. M. Jaeger, T. M. Petterson et al. // Mayo Clin. Proc. – 1995. – Vol. 70. – P. 725–733.
24. Higashi, M. Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy / M. Higashi, D. Veenstra, L. Kondo // J. Am. Med. Ass. – 2002. – Vol. 287. – P. 1690–1698.
25. Hu, A. Factors influencing patient knowledge of warfarin therapy after mechanical heart valve replacement / A. Hu, C. Chow, D. Dao // J. Cardiovasc. Nurs. – 2006. – Vol. 21. – P. 169–175.
26. Jackson, S. Accuracy, reproducibility and clinical utility of the CoaguChek S portable international normalized ratio monitor in an outpatient anticoagulation / S. Jackson, L. Bereznicki, G. Peterson // Сlin. Laborat. Haematol. – 2004. – Vol. 26. – P. 49–55.
27. Klein, T. Estimation of the warfarin dose with clinical and pharmacogenetic data / T. Klein, R. Altman, N. Eriksson // N. Engl. J. Med. – 2009. – Vol. 360. – P. 753–764.
28. Kurohara, M. Low-dose warfarin functions as an immunomodulator to prevent cyclophosphamideinduced NOD diabetes / M. Kurohara // Kobe J. Med. Sci. – 2008. – Vol. 23, № 54 (1). – P. 1–13.
29. Landefeld, C. S. Major bleeding in outpatients treated with warfarin: incidence and prediction by factors known at the start of outpatient therapy / C. S. Landefeld, L. Goldman // Am. J. Med. – 1989. – Vol. 87. – P. 144–151.
30. Macik, B. G. The future of anticoagulation clinics / B. G. Macik // J. Thromb. Thrombolys. – 2003. – Vol. 16. – P. 55–59.
31. McIntyre, K. Medicolegal implications of consensus statements / K. McIntyre // Chest. – 1995. – Vol. 8. – P. 502–505.
32. Mergenhagen, K. A. Elevated International Normalized Ratio after concurrent ingestion of cranberry sauce and warfarin / K. A. Mergenhagen, O. Sherman // Am. J. Health Syst. Pharm. – 2008. – Vol. 15, № 65. – P. 2113–2116.
33. Norton, J. Establishing an outpatient anticoagulation clinic in a community hospital / J. Norton, D. Gibson // Am. J. Health-system Pharmacy. – 1996. – Vol. 53. – P. 1151–1157.
34. Nutescu, E. The future of anticoagulation clinics / E. Nutescu // Thromb. Thrombolys. – 2003. – Vol. 16. – P. 61–63.
35. Palareti, G. Bleeding complications of oral anticoagulant treatment: an inception-cohort, prospective collaborative study (ISCOAT) / G. Palareti, N. Leali, S. Coccheri // Lancet. – 1996. – Vol. 348. – P. 423–428.
36. Poller, L. An assessment of lyophilised plasmas for ISI calibration of CoaguChek and TAS whole blood prothrombin time monitors / L. Poller, M. Keown, N. Chauhan // J. Clin. Pathol. – 2003. – Vol. 56. – P. 114–119.
37. Roche-Nagle, G. Evaluation of patient knowledge regarding oral anticoagulants / G. Roche-Nagle, F. Chambers, J. Nanra // Irish Med. J. – 2003. – Vol. 96. – P. 211–213.
38. Rosendaal, F. The Scylla and Charybdis of oral anticoagulant treatment / F. Rosendaal // Circulation. – 1996. – Vol. 335, № 8. – P. 587–589.
39. Sam, C. The management of warfarin therapy by anticoagulation clinics: results of a forum survey / C. Sam, J. Speckman, M. Moskowitz // Anticoagul. Forum. – 2000. – Vol. 5. – P. 1–3.
40. Taylor, F. Methods for managing the increased workload in anticoagulant clinic / F. Taylor, M. Ramsay, A. Renton // BMJ. – 1996. – Vol. 286. – P. 312.
41. Van den Besselaar, A. M. Standardization of the prothrombin time in oral anticoagulant control / A. M. Van den Besselaar // Haemostasis. – 1985. – Vol. 15, № 4. – P. 271–277.
42. Waterman, A. Establishing and running an effective telephone-based anticoagulation service / A. Waterman, P. Milligan, G. Banet // J. Vasc. Nursing. – 2001. – Vol. 19. – P. 126–132.
43. Wilson, Jo-A. Comparing the quality of oral anticoagulant management by anticoagulation clinics and by family physicians: a randomized controlled trial S / Jo-A. Wilson, Ph. S. Wells, M. J. Kovacs et al. // CMAJ. – 2003. – Vol. 169. – P. 293–298.
44. Witt, D. A retrospective evaluation of the management of excessive anticoagulation in an established clinical pharmacy anticoagulation service compared to traditional care / D. Witt, T. Humphries // J. Thromb. Thrombolys. – 2003. – Vol. 15. – P. 113–118.
45. Witt, D. The Kaiser Permanente Colorado Clinical Pharmacy Anticoagulation Service as a model of modern anticoagulant care / D. Witt // Trombosis Research. – 2008. – Vol. 123. – P. 36–41.
Abstract
Now, thrombotic complications such as an ischemic stroke etc. are one of the leading reasons of cardiovascular death and the hospitalisation bringing a huge economic damage to the state. Long therapy by oral anticoagulants (warfarin) remains the extremely important, uncontested and obligatory indication at persons with the constant form of atrium fibrillation, the prosthesis heart valves, a thrombosis of deep veins. Even at careful observance of rules and schemes of dispensing of preparations at selection with control the international normalised retio (INR), against treatment at the patient probably development of adverse reactions in the form of bleedings including lifethreatening. It should will be reflected in adherence of therapy by oral anticoagulants both at patients and at the doctors.The therapy by oral anticoagulants complicated by bleedings, can lead to additional expenses at the expense of additional visits to the doctor, analyses, to hospitalisation or its prolongation, and insufficient level of the control of coagulation or death. However, in many developed countries this situation has been overcome by creation so-called specialised anticoagulants clinics. Numerous researches say that this measure has appeared economically justified since has led to decrease in frequency of ischemic strokes, hospitalisation etc. Besides, supervision of patients in conditions anticoagulants centres led to decrease in frequency of bleedings at application of oral anticoagulants in 2-3 times. In article are resulted the information on structure, functional features and possibilities anticoagulants clinics, possible prospects of their development reveal.
References
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3. Ansell, J. Managing oral anticoagulant therapy / J. Ansell, J. Hirsh, J. Dalen et al. // Chest. – 2001. – Vol. 119. – P. 22–38.
4. Ansell, J. The anticoagulation guidelines task force. Consensus guidelines for coordinated outpatient oral anticoagulation therapy management / J. Ansell, M. Buttaro, O. Thomas // Ann. Pharmacother. – 1997. – Vol. 31. – P. 604–615.
5. Anticoagulants in the Secondary Prevention of Events in Coronary Thrombosis (ASPECT) Research Group. Effect of long-term oral anticoagulant treatment on mortality and cardiovascular morbidity after myocardial infarction // Lancet. – 1994. – Vol. 343. – P. 499–503.
6. Berrettini, M. Anticoagulation clinics: the Italian experience / M. Berrettini // Haematologica. – 1997. – Vol. 82. – P. 713–717.
7. Berrettini, M. Management of oral anticoagulant therapy in Italy / M. Berrettini, G. Agnelli // Seminars in thrombosis and hemostasis. – 1999. – Vol. 25, № 1. – P. 27–31.
8. Beyth, R. Prospective evaluation of an index for predicting the risk of major bleeding in outpatients treated with warfarin / R. Beyth, L. Quinn, S. Landefeld // Am. J. Med. – 1998. –Vol. 105. – P. 91–99.
9. Bond, C. Pharmacist-provided anticoagulation management in United States hospitals: death rates, length of stay, Medicare charges, bleeding complications, and transfusions / C. Bond, C. Raehl // Pharmacotherapy. – 2004. – Vol. 24. – P. 953–963.
10. Breukink-Engbers, W. Monitoring therapy with anticoagulants in the Netherlands / W. Breukink- Engbers // Seminars in thrombosis and hemostasis. – 1999. – Vol. 25. – P. 37–42.
11. Briggs, A. The development and performance validation of a tool to assess patient anticoagulation knowledge / A. Briggs, T. Jackson, S. Bruce // Research in Social & Administrative Pharmacy. – 2005. – Vol. 1. – P. 40–59.
12. Chamberlain, M. Comparison of anticoagulation clinic patient outcomes with outcomes from traditional care in a family medicine clinic / M. Chamberlain, N. Sageser, D. Ruiz // J. Am. Board Family Pract. – 2001. – Vol. 14. – P. 16–21.
13. Chiquette, E. Comparison of an anticoagulation clinic with usual medical care: anticoagulation control, patient outcomes, and health care costs / E. Chiquette, M. Amato, H. Bussey // Arch. Internal. Med. – 1998. – Vol. 158. – P. 1641–1647.
14. Conte, R. Nine-year experience with a pharmacistmanaged anticoagulation clinic / R. Conte, W. Kehoe, N. Nielson // Am. J. Hosp. Pharm. – 1986. – Vol. 43. – P. 2460–2464.
15. Dager, W. Optimization of inpatient warfarin therapy: impact of daily consultation by a pharmacistmanaged anticoagulation service / W. Dager, J. Branch, J. King // Ann. Pharmacother. – 2000. – Vol. 34. – P. 567–572.
16. Denas, G. Effectiveness and safety of a management protocol to correct over-anticoagulation with oral vitamin K: a retrospective study of 1,043 cases / G. Denas, F. Marzot, P. Offelli // J. Thromb. Thrombolysis. – 2008. – Vol. 82. – P. 168–171.
17. Ederhy, S. Strategies for primary and secondary stroke prevention in atrial fibrillation. 2006 / S. Ederhy, A. Cohen // Expert Opinion on Pharmacotherapy. – 2008. – Vol. 66. – P. 327–333.
18. Ernst, M. Evaluation of 4 years of clinical pharmacist anticoagulation case management in a rural, private physician office / M. Ernst, K. Brandt // J. Am. Pharmac. Ass. – 2003. – Vol. 43. – P. 630–636.
19. Farnsworth, F. Centralized, pharmacist-managed anticoagulation service for a university-based health system / F. Farnsworth, K. Kim, M. Jacobs // Am. J. Health-system Pharm. – 2001. – Vol. 58. – P. 77–78.
20. Francavilla, C. Registered nurse-managed anticoagulation clinic: improving patient outcomes / C. Francavilla // Nursing Economic. – 2008. – Vol. 26. – P. 130–132.
21. Franke, A. Improving anticoagulation therapy using point-of-care testing and a standardized protocol / A. Franke, M. J. Dickerson, P. Carek // Ann. Fam. Med. – 2008. – Vol. 6. – P. 28–32.
22. Gadisseur, A. Patient self-management of oral anticoagulant care vs. management by specialized anticoagulation clinics: positive effects on quality of life / A. Gadisseur, A. Kaptein // J. Thromb. Haemost. – 2004. – Vol. 2, № 4. – P. 584–591.
23. Glitter, M. J. Bleeding and thromboembolism during anticoagulant therapy: a population-based study in Rochester, Minnesota / M. J. Glitter, T. M. Jaeger, T. M. Petterson et al. // Mayo Clin. Proc. – 1995. – Vol. 70. – P. 725–733.
24. Higashi, M. Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy / M. Higashi, D. Veenstra, L. Kondo // J. Am. Med. Ass. – 2002. – Vol. 287. – P. 1690–1698.
25. Hu, A. Factors influencing patient knowledge of warfarin therapy after mechanical heart valve replacement / A. Hu, C. Chow, D. Dao // J. Cardiovasc. Nurs. – 2006. – Vol. 21. – P. 169–175.
26. Jackson, S. Accuracy, reproducibility and clinical utility of the CoaguChek S portable international normalized ratio monitor in an outpatient anticoagulation / S. Jackson, L. Bereznicki, G. Peterson // Сlin. Laborat. Haematol. – 2004. – Vol. 26. – P. 49–55.
27. Klein, T. Estimation of the warfarin dose with clinical and pharmacogenetic data / T. Klein, R. Altman, N. Eriksson // N. Engl. J. Med. – 2009. – Vol. 360. – P. 753–764.
28. Kurohara, M. Low-dose warfarin functions as an immunomodulator to prevent cyclophosphamideinduced NOD diabetes / M. Kurohara // Kobe J. Med. Sci. – 2008. – Vol. 23, № 54 (1). – P. 1–13.
29. Landefeld, C. S. Major bleeding in outpatients treated with warfarin: incidence and prediction by factors known at the start of outpatient therapy / C. S. Landefeld, L. Goldman // Am. J. Med. – 1989. – Vol. 87. – P. 144–151.
30. Macik, B. G. The future of anticoagulation clinics / B. G. Macik // J. Thromb. Thrombolys. – 2003. – Vol. 16. – P. 55–59.
31. McIntyre, K. Medicolegal implications of consensus statements / K. McIntyre // Chest. – 1995. – Vol. 8. – P. 502–505.
32. Mergenhagen, K. A. Elevated International Normalized Ratio after concurrent ingestion of cranberry sauce and warfarin / K. A. Mergenhagen, O. Sherman // Am. J. Health Syst. Pharm. – 2008. – Vol. 15, № 65. – P. 2113–2116.
33. Norton, J. Establishing an outpatient anticoagulation clinic in a community hospital / J. Norton, D. Gibson // Am. J. Health-system Pharmacy. – 1996. – Vol. 53. – P. 1151–1157.
34. Nutescu, E. The future of anticoagulation clinics / E. Nutescu // Thromb. Thrombolys. – 2003. – Vol. 16. – P. 61–63.
35. Palareti, G. Bleeding complications of oral anticoagulant treatment: an inception-cohort, prospective collaborative study (ISCOAT) / G. Palareti, N. Leali, S. Coccheri // Lancet. – 1996. – Vol. 348. – P. 423–428.
36. Poller, L. An assessment of lyophilised plasmas for ISI calibration of CoaguChek and TAS whole blood prothrombin time monitors / L. Poller, M. Keown, N. Chauhan // J. Clin. Pathol. – 2003. – Vol. 56. – P. 114–119.
37. Roche-Nagle, G. Evaluation of patient knowledge regarding oral anticoagulants / G. Roche-Nagle, F. Chambers, J. Nanra // Irish Med. J. – 2003. – Vol. 96. – P. 211–213.
38. Rosendaal, F. The Scylla and Charybdis of oral anticoagulant treatment / F. Rosendaal // Circulation. – 1996. – Vol. 335, № 8. – P. 587–589.
39. Sam, C. The management of warfarin therapy by anticoagulation clinics: results of a forum survey / C. Sam, J. Speckman, M. Moskowitz // Anticoagul. Forum. – 2000. – Vol. 5. – P. 1–3.
40. Taylor, F. Methods for managing the increased workload in anticoagulant clinic / F. Taylor, M. Ramsay, A. Renton // BMJ. – 1996. – Vol. 286. – P. 312.
41. Van den Besselaar, A. M. Standardization of the prothrombin time in oral anticoagulant control / A. M. Van den Besselaar // Haemostasis. – 1985. – Vol. 15, № 4. – P. 271–277.
42. Waterman, A. Establishing and running an effective telephone-based anticoagulation service / A. Waterman, P. Milligan, G. Banet // J. Vasc. Nursing. – 2001. – Vol. 19. – P. 126–132.
43. Wilson, Jo-A. Comparing the quality of oral anticoagulant management by anticoagulation clinics and by family physicians: a randomized controlled trial S / Jo-A. Wilson, Ph. S. Wells, M. J. Kovacs et al. // CMAJ. – 2003. – Vol. 169. – P. 293–298.
44. Witt, D. A retrospective evaluation of the management of excessive anticoagulation in an established clinical pharmacy anticoagulation service compared to traditional care / D. Witt, T. Humphries // J. Thromb. Thrombolys. – 2003. – Vol. 15. – P. 113–118.
45. Witt, D. The Kaiser Permanente Colorado Clinical Pharmacy Anticoagulation Service as a model of modern anticoagulant care / D. Witt // Trombosis Research. – 2008. – Vol. 123. – P. 36–41.
