Significance of lipoprotein (A) in the pathogenesis of cardiovascular diseases HTML

Authors: M.B. Yaroustovsky, M.V. Abramyan

Company: Bakoulev National Medical Research Center for Cardiovascular Surgery of Ministry of Health of the Russian Federation, Rublevskoe shosse, 135, Moscow, 121552, Russian Federation

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Heading: Reviews

UDC: 616.1-092:577.112.856
DOI: https://doi.org/10.24022/1997-3187-2019-13-1-40-51

For citation: Yaroustovsky M.B., Abramyan M.V. Significance of lipoprotein (a) in the pathogenesis of cardiovascular diseases. Creative Cardiology. 2019; 13 (1): 40–51 (in Russ.). DOI: 10.24022/1997-3187-2019-13-1-40-51

Received / Accepted:  10.01.2019/15.01.2019

Key Words: atherosclerosis lipoprotein (a) lipid disorders dyslipidemia cardiovascular diseases

Abstract

The progress of medical technology allows you to look at the problem of the treatment of atherosclerosis and its complications more widely. The development of atherosclerosis depends on many factors, leading among which are dyslipidemia. In clinical practice, there are patients with atherosclerotic lesions of various vessels with normal or slightly elevated lipid levels, which is the reason for skepticism of some doctors about lipid theory. It is clear, that absolutization of the role of lipoproteins, as the best indicators of the risk of ischemic lesions, can lead to an erroneous understanding of the pathogenesis. This suggests the presence of other etiological factors of atherosclerosis. Among the lipid factors, not only high levels of low density lipoproteins (LDL), but also lipoprotein (a) (Lp(a)) have made a certain contribution to the development of atherosclerosis. Today, Lp(a) is even considered an independent risk factor for thrombogenesis and atherogenesis, and a predictor of cardiovascular and microvascular diseases. The structural and functional identity of Lp(a) with LDL and plasminogen determine its role in the pathogenesis of atherothrombosis. The results of many studies indicate the adverse effects of hyperlipoproteidemia on the cardiovascular system. The definition of Lp(a) is important and useful for the early prevention of complications and, if necessary, the choice of treatment.

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About Authors

  • Mikhail B. Yaroustovsky, Professor, Corresponding Member of Russian Academy of Sciences, Deputy Director, Head of Department, orcid.org/0000-0002-1849-4745;
  • Marina V. Abramyan, Cand. Med. Sc., Leading Researcher, orcid.org/0000-0001-6200-7855

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, Director of Bakoulev National Medical Research Center for Cardiovascular Surgery