The relationship between lipid, calciumand phosphorus metabolism, severety of coronaryartery lesions and osteopenia in elderly patientswith coronary artery disease

Authors: Barbarash O.L.1,2, 2, Kashtalap V.V.1,2, 2, Zykov M.V.1, Khryachkova O.N.1, Novitskaya A.A.1, Kokov A.N.1, Shibanova I.A.1, Raskina T.A.2

Company: 1 Research Institute for Complex Issues of Cardiovascular Diseases; Sosnovyy bul’var, 6, Kemerovo, 650002, Russian Federation;
2 Kemerovo State Medical Academy of Ministry of Health of the Russian Federation; ulitsa Voroshilova, 22a, Kemerovo, 650029, Russian Federation

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Type:  Heart valve and coronary artery calcification


For citation: Barbarash O.L., Kashtalap V.V., Zykov M.V. et al. The relationship between lipid, calcium and phosphorus metabolism, severety of coronary artery lesions and osteopenia in elderly patients with coronary artery disease. Kreativnaya Kardiologiya. 2016; 10 (2): 117-127 (in Russian)

Keywords: coronary atherosclerosis coronary artery disease calcification dyslipidemia osteopenic syndrome hypogonadism

Full text:  



Objective. To identify the relationship between the severity of coronary atherosclerosis, coronary calcification, osteopenic syndrome and functional parameters of bone metabolism and dyslipidemia in elderly patients with stable coronary artery disease (CAD).

Material and methods. 57 elderly male patients (the median age of 65 [62; 69] years) with stable CAD were included in the study. The severity of coronary atherosclerosis and coronary artery calcification was assessed by the number of significant coronary artery lesions and SYNTAX score; multislice computed tomography (MSCT) with the quantitative analysis of coronary calcification and the measurement of the coronary artery calcium score by the Agatston method (CaScore); the presence of osteopenic syndrome was diagnosed by dual energy X-ray absorptiometry; the severity of dyslipidemia and bone metabolism disorders were assessed using blood serum analysis.

Results. Reduced bone mineral density was associated with the severity of coronary atherosclerosis assessed by the SYNTAX score and quantitative parameters of coronary artery calcification (CaScore). The relationship between biomarkers of bone metabolism disorders, lipid profile and coronary artery calcification scores has not been observed. However, patients with severe atherosclerosis demonstrated higher osteopontin levels. A tendency to elevated estradiol levels in patients with severe coronary atherosclerosis, assessed by the SYNTAX score, has been found.

Conclusion. The correlation between reduced bone mineral density and the severity of coronary atherosclerosis and calcification has been found in elderly male patients with stable CAD. Metabolic correlates of osteopenic syndrome and coronary atherosclerosis have been identified.


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About Authors

  • Barbarash Ol’ga Leonidovna, MD, DM, Professor, Director of Research Institute for Complex Issues of Cardiovascular Diseases, Chief of Chair;
  • Kashtalap Vasiliy Vasil’evich, MD, DM, Chief of Laboratory, Associate Professor;
  • Zykov Mikhail Valer’evich, MD, PhD, Research Associate;
  • Khryachkova Oksana Nikolaevna, Junior Research Associate;
  • Novitskaya Anastasiya Aleksandrovna, Cardiologist;
  • Kokov Aleksandr Nikolaevich, MD, PhD, Chief of Laboratory;
  • Shibanova Irina Aleksandrovna, MD, PhD, Senior Research Associate;
  • Raskina Tat'yana Alekseevna, MD, DM, Professor, Chief of Chair

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery