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Forecasting the myocardial infarction complications duringone year applying genetic polymorphisms

Authors: Inozemtseva A.A.1, Kashtalap V.V.1, Gordeeva L.A.2, Kagan E.S.3, Barbarash O.L.1

Company: 1Research Institute for Complex Issues of Cardiovascular Diseases; Sosnovyy bul'var, 6, Kemerovo, 650002, Russian Federation;
2 Institute of Human Ecology of the Siberian Branch of the Russian Academy Sciences; Leningradskiy prospekt, 10, Kemerovo, 650000, Russian Federation;
3 Kemerovo State University; ulitsa Krasnaya, 6, Kemerovo, 650043, Russian Federation

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DOI: https://doi.org/10.15275/kreatkard.2016.04.02

For citation: Inozemtseva A.A., Kashtalap V.V., Gordeeva L.A., Kagan E.S., Barbarash O.L. Forecasting the myocardial infarction complications duringone year applying genetic polymorphisms. Creative Cardiology. 2016; 10 (4): 281-289 (in Russ.).

Keywords: myocardial infarction genetic polymorphisms prediction complications atherosclerosis

Full text:  

 

Abstract

Objective. To form a new risk scale of adverse annual prognosis in ST-elevation myocardial infarction (STEMI) patients using clinical, laboratory and genetic parameters.
Material and methods. 358 patients with STEMI of less than 24 hours were examined. Besides routine clinical methods of examination the risk scores were calculated by TIMI, CADILLAC, GRACE risk scales, and genotyping of following polymorphisms was performed: APOA1 (rs670), APOA5 (rs662799), АРОЕ (rs429358, rs7412), LPL (rs328), CETP (rs5882), ACE (rs4341, rs4343). A year later the adverse cases were analyzed which were: death, recurrent myocardial infarction, repeated hospitalization due to progressing of ischemic heart disease and chronic heart failure decompensation.
Results. The analysis of clinical, medical history, laboratory, genetic factors influencing the prognosis and using binary logistic regression new scale is created. It was revealed that existing scales are not effective enough for prognosis of adverse annual events in patients after STEMI, whereas the new scale including clinical, laboratory and genetic indicators possesses a high prognostic ability (AUC=0.77).
Сonclusion. Using the new scale is possible to estimate the annual prognosis and increase the secondary preventive efficiency.

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Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


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