Сосудистые когнитивные расстройства и артериальная ригидность при цереброваскулярной и кардиальной патологии
Abstract
In order to study the relationship of arterial stiffness (AS) and cognitive functions of 77 patients (30 men and 47 women, mean age 61 ± 11 year) with multiple cardiovascular risk factors or chronic cerebrovascular diseases (CVD), or cardiac pathology were examined. AS was assessed with 24-hour blood pressure monitoring and application software «Vasotens» (MnSDP-3, BPLab, «Peter Telegin», Russia). One group consisted of 38 (49%) patients without cognitive impairment, 2 group - 39 (51%) patients with mild cognitive impairment. Both groups were comparable by CVD rate. Patients from group 2 were older and more often suffered from congestive heart failure and coronary artery diseases. AS were significantly higher in second group. Among all patients negative correlation between cognitive score and indicators of AS was found.References
1. Бойцов, С. А. Сосуды как плацдарм и мишень артериальной гипертонии / С. А. Бойцов // Актуальн. вопр. болезней серд. и сосуд. – 2006. – № 1. – С. 35–40.2. Захаров, В. В. Инсульт и когнитивные нарушения / В. В. Захаров, Н. В. Вахнина // Неврол., нейропсихиатр. и психосом. – 2011. – № 2. – С. 8–16.
3. Захаров, В. В. Нарушения памяти / В. В. Захаров, В. В. Яхно. – М.: ГЭОТАР-Медиа, 2003. – 160 с.
4. Кобалава, Ж. Д. Достижения и проблемы современных исследований антигипертензивных препаратов / Ж. Д. Кобалава, Ю. В. Котовская // Кардиология. – 2011. – № 1. – С. 91–99.
5. Орлова, Я. А. Жесткость артерий как интегральный показатель сердечно-сосудистого риска: физиология, методы оценки и медикаментозной коррекции / Я. А. Орлова, Ф. Т. Агеев // Сердце. – 2006. – № 2. – С. 65–70.
6. Орлова, Я. А. Жесткость артерий как предиктор сердечно-сосудистых осложнений при ИБС / Я. А. Орлова, Ф. Т. Агеев // Тер. архив. – 2010. – № 1. – С. 71–79.
7. Agabiti-Rosei, E. Consensus document central blood pressure measurements and antihypertansive therapy: a consensus document / E. Agabiti-Rosei, G. Mancia, M. F. O`Rourke et al. // Hypertension. – 2007. – Vol. 50. – P. 154–160.
8. Benetos, A. Determination of accelerated progression of arterial stiffness in normotensive subject and treated hypertensive subject over a 6-year period / A. Benetos, C. Adamopoulos, J. M. Bureau et al. // Circulation. – 2002. – Vol. 105, № 10. – P. 1202–1207.
9. Breithaupt-Grogler, K. Epidemiology of arterial stiffness / K. Breithaupt-Grogler, G. G. Belz // Pathol. Biol. (Paris). – 1999. – Vol. 47. – P. 604–613.
10. Caplan, L. R. Cardiac encephalopathy and congestive heart failure: a hypothesis about the relationship / L. R. Caplan // Neurology. – 2006. – Vol. 66. – P. 99–101.
11. Cruickshank, K. Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function? / K. Cruickshank, L. Riste, S. G. Anderson et al. // Circulation. – 2002. – Vol. 106. – P. 2085–2090.
12. Dubois, B. The FAB: a frontal assessment battery at bedside / B. Dubois, A. Slachevsky, I. Litvan et al. // Neurology. – 2000. – Vol. 55. – P. 1621–1626.
13. Feugeas, M. C. H. Age-related cerebral white matter changes and pulse-wave encephalopathy: observations with three-dimensional MRI / M. C. H. Feugeas, G. De Marco, I. I. Peretti et al. // Magn. Reson. Imaging. – 2005. – Vol. 23. – P. 929–937.
14. Gorelick, Ph. B. Vascular contribution to cognitive impairment and dementia. A statement for healthcare professionals from the American Heart Association / American Stroke Association / Ph. B. Gorelick, A. Scuteri, S. E. Black et al. // Stroke. – 2011. – Vol. 42. – P. 227–276.
15. Hachinski, V. C. Multi-infarct dementia. A case of mental deterioration in the elderly / V. C. Hachinski, M. A. Lassen, J. Marshall // Lancet. – 1974. – Vol. 2. – P. 107–210.
16. Hanon, O. Relationship between arterial stiffness and cognitive function in elderly subjects with complaints of memory loss / O. Hanon, S. Haulon, H. Lenoir et al. // Stroke. – 2005. – Vol. 36. – P. 2193–2197.
17. Hansen, T. W. Ambulatory arterial stiffness index predicts stroke in a general population / T. W. Hansen, J. A. Staessen, C. Torp-Pedersen et al. // J. Hypertens. – 2006. –Vol. 24. – P. 2247–2253.
18. Hatanaka, R. Association of arterial stiffness with silent cerebrovascular lesions: The Ohasama Study / R. Hatanaka, T. Obara, D. Watabe et al. // Cerebrovasc. Dis. – 2011. – Vol. 31. – P. 329–337.
19. Laurent, S. Aortic stiffness is independent predictor of fatal stroke in essential hypertension/ S. Laurent, S. Katsahian, C. Fassot et al. // Stroke. – 2003. – Vol. 34. – P. 1203–1206.
20. Laurent, S. Expert consensus document on arterial stiffness: methodological issues and clinical applications / S. Laurent, J. Cockcroft, L. Van Bortel et al. // Eur. Heart J. – 2006. –Vol. 27. – P. 2588–2605.
21. London, G. M. Cardiovascular disease in chronic renal failure: pathophysiologic aspects / G. M. London // Semin. Dial. – 2003. – Vol. 16. – P. 85–94.
22. Mattace-Raso, F. U. Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study / F. U. Mattace-Raso, T. J. van der Cammen, A. Hofman et al. // Circulation. – 2006. – Vol. 113. – P. 657–663.
23. Mitchel, G. F. Effects of central arterial aging on the structure and function of the peripheral vasculature: implication for end-organ damage / G. F. Mitchel // J. Appl. Physiol. – 2008. – Vol. 105. – P. 1652–1660.
24. Nichols, W. W. McDonald’s blood flow in arteries: theoretical, experimental and clinical principles / W. W. Nichols, M. F. O’Rourke. – 5th ed. – London: Hodder Arnold, 2005.
25. Nilsson, P. M. Vascular aging: A tale of EVA and ADAM in cardiovascular risk assessment and prevention / P. M. Nilsson, P. Boutouyrie, S. Laurent // Hypertension. – 2009. – Vol. 54. – P. 3–10.
26. O’Rourke, M. F. Relationship between aortic stiffness and microvascular disease in brain and kidney: cause and logic of therapy / M. F. O’Rourke, M. E. Safar // Hypertens. – 2005. – Vol. 46. – P. 200–204.
27. Pase, M. P. Healthy middle-aged individuals are vulnerable to cognitive deficits as a result of increased arterial stiffness / M. P. Pase, A. Pipingas, M. Kras et al. // J. Hypertens. – 2010. – Vol. 28. – P. 1724–1729.
28. Sassalos, K. The acute and chronic effect of cigarette smoking on the elastic properties of the ascending aorta in healthy male subjects / K. Sassalos, C. Vlachopoulos, N. Alexopoulos et al. // Hellenic. J. Cardiol. – 2006. – Vol. 47. – P. 263–268.
29. Scuteri, A. Arterial stiffness is an independent risk factor for cognitive impairment in the elderly: a pilot study / A. Scuteri, A. M. Brancati, W. Gianni et al. // J. Hypertens. – 2005. – Vol. 23. – P. 1211–1216.
30. Vidal, J. S. Coronary artery calcium, brain function and structure: the AGES-Reykjavik Study / J. S. Vidal, S. Sigurdsson, M. K. Jonsdottir et al. // Stroke.– 2010. – Vol. 41. – P. 891–897.
31. Vlachopoulos, C. Aortic stiffness: prime time for integration into clinical practice / C. Vlachopoulos, N. Alexopoulos, Ch. Stefanadis // Hellenic. J. Cardiol. – 2010. – Vol. 51. – P. 385–390.
32. Vlachopoulos, C. Genesis of the normal and abnormal arterial pulse / C. Vlachopoulos, M. O’Rourke // Curr. Probl. Cardiol. – 2000. – Vol. 25. – P. 303–367.
33. Waldstein, S. R. Pulse pressure and pulse wave velocity are related to cognitive decline in the Baltimore Longitudinal Study of Aging / S. R. Waldstein, S. C. Rice, J. F. Thayer et al. // Hypertens. – 2008. – Vol. 51. – P. 99–104.
