Эндотелийзависимая вазодилатация плечевой артерии у пациентов с кардиомиопатией такотсубо

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Abstract

Background. Tako-Tsubo cardiomyopathy (TTC) is associated with transient myocardial contractile dysfunction. The purpose of this study was to investigate brachial artery flow-mediated dilation (FMD) in patients with TTC.

Methods. We compared the results of FMD tests of 5 women with TTC with the results of 18 women with ST elevation acute myocardial infarction (STEMI) and of 26 healthy female volunteers. FMD tests in all patients were performed within 24 hours of admission and again at 1-3 weeks as a follow-up.

Results. The FMD levels were lower at the acute phase in patients with TTC than in patients with STEMI and in healthy volunteers (p < 0. 01). After 1-3 weeks, the FMD test results of patients with TTC had greatly increased, and no significant differences were found between these results and the results from patients with STEMI (p>0.05). There were no significant differences in the FMD test results between the group of patients with TTC and the group of healthy volunteers (p>0.05).

Conclusions. There is a pronounced and reversible endothelial dysfunction in patients with TTC, which can impair myocardial perfusion.

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Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery