Coronary artery bypass grafting outcomes in patients with different body weight
Authors:
Company:
Research Institute for Complex Issues of Cardiovascular Diseases, Siberian Branch of the Russian Academy of Medical Sciences; Sosnovyy
bul’var, 6, Kemerovo, 650002, Russian Federation
For citation: Altarev S.S., Barbarash O.L. Coronary artery bypass grafting outcomes in patients with different body weight. Creative Cardiology. 2014; 1: 5-15
Keywords: coronary artery bypass grafting body weight body mass index outcomes complications.
Abstract
Objective. To determine coronary artery bypass outcomes depending on body mass index.Material and methods. We analyzed the pooled data of the coronary artery bypass grafting (CABG) Registries which had been carried out in the Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation, in 2009 and 2011. Primary end-point included all cases of myocardial infarction, transitory ischemic attack, stroke, cardiac arrest, and death in perioperative and early postoperative periods. Primary safety end-point included all cases of re-operations for bleeding in a postoperative period.
Results. Data of 1414 patients were analyzed, of which 316 (22.3%) patients had body mass index (BMI) of less than 25.0. Primary end-point was more frequent in the patients with BMI less than 25.0 than in overweight or obese patients (7.0 vs 3.1%, respectively, p=0.002), while resternotomy rates were similar in the both groups of patients (2.8 vs 1.9%, respectively, p=0.31). After adjustment for all factors, having BMI less than 25.0 was associated with higher primary end-point risk (odds ratio (OR) 3.0, 95% contingency interval (CI) 1.4–6.5), moreover, underweight/normal weight patients tended to more frequently undergo re-operations for bleeding (OR 2.0, 95% CI 0.7–5.4). Regression analysis showed U-shaped relationships between BMI and primary end-point.
Conclusion. We showed that there was association between patients’ body weight and postoperative cerebral and cardiovascular events and death, which might be non-linear. Also, the patients with BMI less than 25.0 tended to more frequently undergo reoperations for bleeding.
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