Human herpesviruses and atherosclerosis.Modern point of view

Authors: E.A. Nikitskaya 1, E.V. Maryukhnich 1, P.P Savvinova 1, N.V. Pinegina 1, A.V. Shpektor 1, E.Yu. Vasilieva 1, L.B. Margolis 2

Company: 1) Cardiology Chair for Post-Diploma Education Faculty of A.I. Evdokimov Moscow State Medical-Stomatological University of Ministry of Health of the Russian Federation; Delegatskaya ulitsa, 20, stroenie 1, Moscow, 127473, Russian Federation; 2) The Eunice Kennedy Shriver National Institute of Child Health and Human Development; Center Drive, Building 31, Bethesda, United States


For citation: E.A. Nikitskaya, E.V. Maryukhnich, P.P SavvinovaHuman herpesviruses and atherosclerosis. Modern point of viewCreative Cardiology. 2015; 2: 54-61

Keywords: atherosclerosis coronary artery disease human herpesviruses polymerase chain reaction

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Atherosclerosis is a complicated process, involving genetic and methabolic factors, associated with the interactions between cells of many different types. Mechanisms of plaque destabilization are still not clear and require new investigations. Connections between human herpes viruses (HHV) and atherosclerosis were suggested in 19th century. However, in spite of many studies on the do not know wether HHV play a role in atherosclerosis development and progression since the results of these studies are highly controversial. According to some studies the relations between HHV infection and atherosclerosis exist, but other studies do not confirm this result. Also, controvercial data were published on the prevalence of HHV in atherosclerosis: this prevalence varied 0 to 100%. No doubt that we need further investigations that include determination of the latency/activity of HHV not only in tissue but also in blood of the patients with atherosclerosis.


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Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery