Register
Forgot your password?

Factors associated with the risk of death and hospitalization in recurrent myocar-98 dial infarction

Authors: Sedykh D.Yu. 1 3, Gorbunova E.V. 1 3, Zykov M. V. 1, Kashtalap V. V. 1 2, Barbarash O.L. 1 2

Company: 1 Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovyy bul’var, 6, Kemerovo, 650002, Russian Federation;
2 Kemerovo State Medical University of Ministry of Health of the Russian Federation, ulitsa Voroshilova, 22A, Kemerovo, 650029, Russian Federation;
3 Kemerovo Regional Clinical Cardiology Dispensary named after academician L.S. Barbarash, Sosnovyy bul’var, 6, Kemerovo, 650002, Russian Federation

For correspondence:  Sign in or register.

Type:  Ischemic heart disease


DOI: https://doi.org/10.24022/1997-3187-2017-11-2-98-108

For citation: Sedykh D.Yu., Gorbunova E.V., Zykov M.V., Kashtalap V.V., Barbarash O.L. Factors associated with the risk of death and hospitalization in recurrent myocardial infarction. Kreativnaya kardiologiya (Creative Cardiology, Russian journal). 2017; 11 (2): 98—108 (in Russ.). DOI: http://dx.doi.org/10.24022/1997-3187-2017-11-2-98-108

Keywords: recurrent coronary events myocardial infarction polyvascular disease percutaneous coronary intervention adherence to pharmacotherapy

Full text:  

 

Abstract

Objective. To identify the independent prognostic factors associated with the development of recurrent fatal and nonfatal myocardial infarction (MI).

Material and methods. Based on the database of acute coronary syndrome (ACS) registry in 2009 in Kemerovo Regional Clinical Cardiology Dispensary named after academician L.S. Barbarash 471 patients with primary MI were included into the retro-prospective study. Within 5 years we had been evaluating the endpoints in regard to the development of fatal and nonfatal recurrent MI in order to reveal their independent predictors. All patients were divided into two groups. The first group of people included 346 patients without the diagnosis of RMI, the second - 125 patients with RMI.

Results. During the 5-year observation period the cases of recurrent coronary events are detected: unstable angina was revealed in 126 patients (26.7%) and recurrent MI — in 125 patients (26.5%), fatal MI was detected in 23 (18.4%) of them. The independent predictors of the development of a fatal and nonfatal recurrent MI are: non-Q-wave type of primary MI (odds ratio (OR) 4.012; 95% confidence interval (CI) 2.750—5.853; р = 0.0000), nonexecution of a percutaneous coronary intervention (PCI) at the moment of the primary MI (OR 0.250; 95% CI 0.170—0.366; р = 0.0000), manifestations of polyvascular disease (PolyVD) in the form of cerebral atherosclerosis and atherosclerosis of lower extremity arteries at the moment of inclusion into the registry (OR 2.340; 95% CI 1.343—4.077; р = 0.0030) and the signs of complicated course of primary MI in the form of acute heart failure (AHF) Killip II—IV (OR 2.040; 95% CI 1.174—3.545; р = 0.0011). The factors associated with fatal outcomes of a recurrent myocardial infarction are: age older than 57.7 years (OR 1.053; 95% CI 1.002—1.107; р = 0.042), detection of PolyVD (OR 2.916; 95% CI 0.963—8.833; р = 0.0580) and non-execution of PCI during initial hospitalization (OR 0.253; 95% CI 0.111—0.577; р = 0.0010).

Gonclusion. The detection of predictors of adverse events in patients with primary MI allows to purposefully enhance the therapeutic and preventive measures and to reduce the risk of recurrent cardiovascular events.

References

  1. Kardakov N.L. The level of primary disability afterdiseases of the circulatory system in the RussianFederation for 10 years (1996–2005). RossiyskiyKardiologicheskiy Zhurnal (Russian CardiologyJournal, Russian journal). 2007; 3: 74–6 (in Russ.).

  2. Boytsov S.A. Prevention of noncommunicable dis-eases in the country: from what to do to how to do.Profilakticheskaya Meditsina (Preventive Medicine,Russian journal).2012; 2: 3–10 (in Russ.).

  3. Russia 2015: Statistical Handbook. Moscow; 2016(in Russ.)

  4. Oganov R.G. Preventing cardiovascular diseases isa real way to improve the demographic situation inRussia. Kardiologiya (Cardiology, Russian journal).2007; 1: 4–7 (in Russ.).

  5. Leykina S.M. The pathogenesis of myocardialinfarction in young people. Vrachebnoe delo(Medical Practice, Russian journal). 1995; 1: 6–12.

  6. Eisdorfer C., Esser D.A., Spector A.N. Caring for the elderly. Baltimore: The Jhons Hopkins University Press; 1989: 4-12.

  7. Empana J.P, Ducimetiere P., Arveiler D. et al. Are the Framingham and PROCAM coronary heart disease risk functions applicable to different European populations? Eur. Heart J. 2003; 24: 1903-11.

  8. Handley A.J., Koster R., Monsieurs K., Perkins G.D., Davies S., Bossaert L. European resuscitation council guidelines for resuscitation 2005. Resuscitation. 2006; 69 (2): 351.

  9. Lye M. Heart disease in the elderly. In: Julian D.G., Camm A.J., Fox K.M., Hall RJC, Poole-Wilson P.A. (Eds.) Disease of the heart. 2nd ed. London: WB Saunders; 1996; 71: 1417-29.

  10. Sanfelix-Gimeno G., Peiro S., Ferreros I. et al. Adherence to evidence-based therapies after acute coronary syndrome: a retrospective population-based cohort study linking hospital, outpatient, and pharmacy health information system in Valencia, Spain. JMCP. 2013; 3 (19): 247-57.

  11. Kostis WJ., Deng Y., Pantazopoulos J.S. et al. For the MIDAS14 Study group. Trends in mortality of acute myocardial infarction after discharge from the hospital. Circ. Cardiovasc. Qual. Outcomes. 2010; 3: 581-9.

  12. Chung S.C., Gedeborg R., Nicholas O. et al. Acute myocardial infarction: a comparison of short-term survival in national outcome registries in Sweden and in the UK. Lancet. 2014; 383: 1305-12.

  13. Shah N.S., Huffman M.D., Ning H., Llloyd-Jo-nes D.M. Trends in myocardial infarction secondary prevention: The National Health and Nutritional Examination Survey (NHANES), 1999-2012. J. Am. Heart Assoc. 2015; 4: 1-12.

  14. Peeters A., Mamun A.A., Willekens F., Bonneux L. A cardiovascular life history. A life course analysis of the original Framingham Heart Study cohort. Eur. Heart J. 2002; 23: 458-66.

  15. Bhatt D.L., Eagle K.A., Ohman E.M. et al. For the REACH Registry Investigators. JAMA. 2010; 304 (12): 1350-7.

  16. Boytsov S.A., Dovgalevskiy P.Ya., Gridnev V.I.,Oshchepkova E.V., Dmitriev V.A. Comparativeanalysis of data from Russian and foreign registersof acute coronary syndrome. KardiologicheskiyVestnik (Cardiological Bulletin, Russian journal).2010; 5 (1): 82–6 (in Russ.)

  17. Oshchepkova E.V., Dmitriev V.A., Gridnev V.I.,Dovgalevskiy P.Ya. Assessment of the organizationof medical care for patients with acute coronarysyndrome with an elevation of the ST segment inthe dynamics for 2009 and 2010. In the subjects ofthe Russian Federation implementing the vascularprogram (according to the Russian ACS register).Terapevticheskiy Arkhiv (Therapeutic Archive,Russian journal).2012; 1: 23–9 (in Russ.).

  18. Hamm C., Crea F. The year in cardiology 2013: acute coronary syndromes. Eur. Heart J. 2014; 35 (6): 349-52.

  19. Jernberg Т., Hasvold P, Henriksson M. et al. Cardiovascular risk in post-myocardial infarction patients: nationwide real world data demonstrate the importance of long-term perspective. Eur. Heart J. 2015; 36 (19): 1163-70.

  20. Skrypnik D.V., Reztsov R.Yu., Makarycheva O.V.,Konovalova E.V., Vasilieva E.Yu., Shpektor A.V.Modern approaches to the treatment of acutemyocardial infarction with ST segment elevation.Kreativnaya Kardiologiya (Creative Cardiology,Russian journal).2014; 2: 5–14 (in Russ.).

  21. Okrugin S.A., Garganeeva A.A., Kuzheleva E.A.,Borel’ K.N. Evaluation of the impact of myocar-dial infarction in the anamnesis and pre-infarctionon the duration of the prehospital stage of acutemyocardial infarction. Kompleksnye ProblemySerdechno-Sosudistykh Zabolevaniy (ComplexProblems of Cardiovascular Diseases, Russian jour-nal).2016; 1: 55–9 (in Russ.).

  22. Sorenzen R., Gislason G.H., Fosbol E.L. et al. Initiation and persistence with clopidogrel treatment after acute myocardial infarction: a nationwide study. Br. J. Clin. Pharmacol. 2008; 66: 875-84.

  23. Gislason G.H., Rasmussen J.N., Abildstrom S.Z. et al. Long-term compliance with beta-blockers, angiotensin-converting enzyme inhibitors, and statins after acute myocardial infarction. Eur. Heart J. 2006; 27: 1153-8.

  24. Naderi S.H., Bestwick J.P, Wald D.S. Adherence to drugs that prevent cardiovascular disease: metaanalysis on 376162 patients. Am. J. Med. 2012; 9 (125): 882-7.

  25. Erlikh A.D. Double antiplatelet therapy: the needfor adherence to treatment and the possibility of itsenhancement. Aterotromboz (Atherothrombosis,Russian journal).2014; 2: 25–33 (in Russ.).

  26. Erlikh A.D., Gratsianskiy N.A. et al. RegistryRECORD. Treatment of patients with acute coro-nary syndromes in hospitals with and without thepossibility of performing invasive coronary proce-dures. Kardiologiya (Cardiology, Russian journal).2010; 7: 8–14 (in Russ.).

  27. Erlikh A.D., Kharchenko M.S., Barbarash O.L.et al. Degree of commitment to the implementa-tion of guidelines for the treatment of acute coro-nary syndrome in the clinical practice of Russianhospitals (data from the RECORD-2 register).Kardiologiya (Cardiology, Russian journal).2013; 2:14–22 (in Russ.).

  28. Tolpygina S.N., Polyanskaya Yu.N., Martsevich S.Yu.Treatment of patients with chronic ischemic heartdisease in real clinical practice according to thedata of the “IHD prognosis” register (part 2).Ratsional’naya Farmakoterapiya v Kardiologii(Rational Pharmacotherapy in Cardiology, Russianjournal). 2013; 9 (5): 49–9 (in Russ.).

  29. Fox K.A., Carruthers K.F., Dunbar D.R. et al. Underestimated and under-recognized: the late consequences of acute coronary syndrome (GRACE UK-Belgian Study). Eur. Heart J.2010; 31: 2755-64.

About Authors

  • Sedykh D.Yu., http://orcid.org/0000-0001-7058-2008

  • Gorbunova E.V., http://orcid.org/0000-0002-2327-2637

  • Zykov M.V., http://orcid.org/0000-0003-0954-9270

  • Kashtalap V.V., http://orcid.org/0000-0003-3729-616X

  • Barbarash O.L., http://orcid.org/0000-0002-4642-3610

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Sort by